青春期前阴毛早现——文献综述及两例病例报告。
Premature pubarche during minipuberty - literature review and two case reports.
机构信息
Department of Pediatric Endocrinology and Diabetology, Medical University of Lublin, Poland.
Department of Pediatric Propedeutics, Medical University of Lublin, Poland.
出版信息
Pediatr Endocrinol Diabetes Metab. 2023;29(2):112-117. doi: 10.5114/pedm.2023.129343.
INTRODUCTION
Isolated premature pubarche (PP) in infancy may be the reason for many diagnostic difficulties. This is due to the low incidence and, therefore, the limited number of studies on this subject and the lack of strict laboratory standards because of the physiological variability of gonadotropic hormone and androgen concentrations during minipuberty.
MATERIAL AND METHODS
We aimed to present current knowledge about PP in infancy based on the literature review and 2 cases of male infants with scrotal hair during minipuberty.
RESULTS
Isolated hair in the pubic region in a boy during the period of minipuberty requires differential diagnosis. After excluding serious aetiology, it seems to be a mild, self-limiting variant of precocious puberty. The phenomenon is probably a result of increased sensitivity of the hair follicles to transiently increased androgen concentration.
CONCLUSIONS
Isolated pubic hair in infancy as a mild, self-limiting variant of precocious puberty in infants should be a diagnosis of exclusion. The condition resolves spontaneously, but it absolutely requires further follow-up to exclude serious aetiology in the case of puberty progression.
简介
婴儿期孤立性性早熟（PP）可能是许多诊断困难的原因。这是由于发病率低，因此，关于这个主题的研究数量有限，并且由于在小青春期期间促性腺激素和雄激素浓度的生理变异性，缺乏严格的实验室标准。
材料和方法
我们旨在基于文献复习和 2 例小青春期时阴囊毛发的男婴病例，介绍关于婴儿期 PP 的现有知识。
结果
小青春期时男孩会阴部孤立性毛发需要进行鉴别诊断。在排除严重病因后，它似乎是一种轻微的、自限性早熟变异型。这种现象可能是由于毛囊对短暂增加的雄激素浓度的敏感性增加所致。
结论
婴儿期孤立性阴毛作为婴儿期早熟的一种轻微、自限性变异型，应排除在外。这种情况会自发消退，但在青春期进展的情况下，绝对需要进一步随访以排除严重病因。
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