Saltzman D H, Eron L J, Tuomala R E, Protomastro L J, Sites J G
J Reprod Med. 1986 Aug;31(8):709-12.
A prospective, double-blind study was performed to evaluate the comparative efficacy of single- and multiple-dose antimicrobial prophylaxis for preventing infection in high-risk patients undergoing cesarean section. One hundred fifty-eight patients were randomly assigned to receive either a single perioperative dose of mezlocillin, three doses of mezlocillin or three doses of cefoxitin. The incidence of endometritis was 5.9%, 4.0% and 4.0%, respectively. The incidence of febrile morbidity was 5.9%, 2.0% and 6.1%, respectively. These differences are not statistically significant. The single perioperative dose of mezlocillin was as effective as the three-dose regimen of either mezlocillin or cefoxitin.
进行了一项前瞻性双盲研究，以评估单剂量和多剂量抗菌药物预防剖宫产高危患者感染的相对疗效。158例患者被随机分配接受围手术期单剂量美洛西林、三剂量美洛西林或三剂量头孢西丁。子宫内膜炎的发生率分别为5.9%、4.0%和4.0%。发热性疾病的发生率分别为5.9%、2.0%和6.1%。这些差异无统计学意义。围手术期单剂量美洛西林与美洛西林或头孢西丁的三剂量方案效果相同。
