Powell L C, Dinh T V, Rajaraman S, Hannigan E V, Dillard E A, Yandell R B, To T
J Reprod Med. 1986 Sep;31(9):808-14.
The authors reviewed 50 cases of carcinoma in situ of the vulva treated at the University of Texas Medical Branch, Galveston, from 1975 to 1984. Sixty-two percent of the patients were premenopausal. The most frequent complaint was vulvar itching. Twenty-six percent of the patients were asymptomatic. Recurrences were frequent (25%) and were associated with multifocal lesions, involved surgical margins and the bowenoid histologic type. Superficially invasive carcinoma was detected in 8% of patients, mostly postmenopausal women with simplex histologic types. Immunohistochemical studies failed to detect papillomavirus- or herpesvirus-associated antigens in any of the cases. Follow-up of 48 patients from six months to ten years revealed no mortality from invasive cancer.
作者回顾了1975年至1984年在加尔维斯顿的德克萨斯大学医学分校接受治疗的50例外阴原位癌病例。62%的患者处于绝经前。最常见的症状是外阴瘙痒。26%的患者无症状。复发很常见（25%），且与多灶性病变、手术切缘受累以及鲍温样组织学类型有关。8%的患者检测到浅表浸润性癌，大多是组织学类型为单纯型的绝经后女性。免疫组织化学研究在所有病例中均未检测到乳头瘤病毒或疱疹病毒相关抗原。对48例患者进行了6个月至10年的随访，结果显示无浸润性癌死亡病例。
