Krupp P J, Bohm J W
Obstet Gynecol. 1978 Jun;51(6):702-6.
Topical 5-fluorouracil (5-FU) has proven effective in epidermoid cancers of the head and neck. Its effectiveness has been correlated with the ability of the patient's immunologic system to recognize new antigens. In this study, 8 patients with carcinoma in situ of the vulva were evaluated and treated with topical 5-FU. Evaluation and followup has been completed and the literature reviewed. The overall treatment response rate was 75%. Followup to date has been 3-39 months. Thirty-five cases were reviewed from this series and the literature with a similar outcome.
局部应用5-氟尿嘧啶（5-FU）已被证明对头颈部表皮样癌有效。其有效性与患者免疫系统识别新抗原的能力相关。在本研究中，对8例外阴原位癌患者进行了评估并用局部5-FU进行治疗。评估和随访已完成，并对文献进行了回顾。总体治疗反应率为75%。迄今为止的随访时间为3至39个月。对该系列中的35例病例以及文献中具有类似结果的病例进行了回顾。
