Pipitò Luca, Zinna Giuseppe, Trizzino Marcello, Gioè Claudia, Tolomeo Manlio, Di Carlo Paola, Colomba Claudia, Gibaldi Lidia, Iaria Chiara, Almasio Piero, Cascio Antonio
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G D'Alessandro," University of Palermo, Palermo, Italy; Infectious and Tropical Disease Unit and Sicilian Regional Reference Center for the fight against AIDS, AOU Policlinico "P. Giaccone", 90127 Palermo, Italy; Palermo Fast-Track City, Casa dei Diritti, Via Libertà 45, 90143 Palermo, Italy.
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G D'Alessandro," University of Palermo, Palermo, Italy.
J Infect Public Health. 2023 Nov;16(11):1703-1708. doi: 10.1016/j.jiph.2023.08.023. Epub 2023 Aug 30.
Despite the rising number of people living with human immunodeficiency virus (HIV), there is a lack of knowledge about the factors that lead to PLWHs being hospitalized in worldwide literature. Our study aimed to investigate PLWH admissions in Sicily (Italy) between January 2010 and September 2021 and to analyze the characteristics and risk factors for in-hospital mortality and differences between Italians and foreigners.
Data from the hospital discharge forms of all people living with HIV (PLWH) hospitalized in Sicilian hospitals were retrospectively collected. Age, sex, nationality, length of stay, acquired immunodeficiency syndrome (AIDS), and non-AIDS-related diseases were evaluated using univariate analysis according to in-hospital mortality rates. The factors associated with mortality were included in the logistic regression model.
In total, 5281 admissions from 2726 PLWHs occurred, most of which were related to non-AIDS diseases. Approximately 20 % regarded foreign patients, mainly from Africa. Logistic regression analysis revealed an association between in-hospital mortality and some AIDS- and non-AIDS-related diseases (wasting syndrome, lymphomas, Kaposi sarcomas, progressive multifocal leukoencephalopathy, cryptococcosis, abscesses, sepsis, cardiovascular disease, nephropathy, and respiratory diseases). African patient admissions were significantly associated with tuberculosis, toxoplasmosis, Burkitt lymphoma, and hepatitis B diagnoses.
Our study showed that most hospitalizations were related to non-AIDS-defining diseases, with differences between Italian and foreign patients, mainly from Africa.
尽管感染人类免疫缺陷病毒（HIV）的人数不断增加，但全球文献中缺乏关于导致HIV感染者（PLWH）住院的因素的知识。我们的研究旨在调查2010年1月至2021年9月期间意大利西西里岛PLWH的住院情况，并分析住院死亡率的特征和危险因素以及意大利人和外国人之间的差异。
回顾性收集西西里岛医院所有住院HIV感染者（PLWH）的出院表格数据。根据住院死亡率，采用单因素分析评估年龄、性别、国籍、住院时间、获得性免疫缺陷综合征（AIDS）和非AIDS相关疾病。将与死亡率相关的因素纳入逻辑回归模型。
2726名PLWH共发生5281次住院，其中大多数与非AIDS疾病有关。约20%为外国患者，主要来自非洲。逻辑回归分析显示住院死亡率与一些AIDS和非AIDS相关疾病（消瘦综合征、淋巴瘤、卡波西肉瘤、进行性多灶性白质脑病、隐球菌病、脓肿、败血症、心血管疾病、肾病和呼吸系统疾病）之间存在关联。非洲患者的住院与结核病、弓形虫病、伯基特淋巴瘤和乙肝诊断显著相关。
我们的研究表明，大多数住院与非AIDS定义疾病有关，意大利患者和主要来自非洲的外国患者之间存在差异。
