Grandjean P, Lyngbye T, Hansen O N
J Toxicol Environ Health. 1986;19(3):437-44. doi: 10.1080/15287398609530941.
A total of 245 newly shed deciduous incisors were obtained from 114 first-grade children who each contributed more than one tooth. Lead concentrations averaged about fivefold higher in circumpulpal dentin than in the whole tooth, but the two parameters showed little correlation. A considerable intraindividual variation in lead levels was partly related to tooth type. In particular, whole upper central incisors contained more lead than did other incisors, but the reverse applied to circumpulpal dentin lead concentration. As whole-tooth and circumpulpal lead concentrations may represent different compartments, tooth lead analyses must be interpreted accordingly. Lead levels in circumpulpal dentin would appear to be a meaningful indicator of long-term lead retention in population studies of children.
从114名一年级儿童中获取了总共245颗新脱落的乳牙，每名儿童贡献了不止一颗牙齿。牙髓周牙本质中的铅浓度平均比全牙中的铅浓度高约五倍，但这两个参数之间几乎没有相关性。个体内铅水平的显著差异部分与牙齿类型有关。特别是，上颌中切牙全牙中的铅含量比其他切牙多，但牙髓周牙本质铅浓度情况则相反。由于全牙和牙髓周铅浓度可能代表不同的部分，因此牙齿铅分析必须相应地进行解释。在儿童人群研究中，牙髓周牙本质中的铅水平似乎是长期铅潴留的一个有意义的指标。
