Division of Urology, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan,
Department of Education, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan,
Int Arch Allergy Immunol. 2024;185(1):20-32. doi: 10.1159/000533403. Epub 2023 Sep 20.
Sexual dysfunction (SD) and allergic disease are common health concerns worldwide and bear a potential relationship. This scoping review is conducted to analyze the currently available data regarding the associations between these two health issues.
A comprehensive literature search was performed in the databases of PubMed, MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science to retrieve studies that were published before January 2023. A narrative synthesis was conducted to analyze the effects of allergic diseases on SD based on the evaluation of the Female Sexual Function Index (FSFI) and International Index of Erectile Function (IIEF).
Twelve observational studies were included after the selection process. The results generally suggested lower FSFI or IIEF scores in patients with asthma, allergic rhinitis, allergic rhinoconjunctivitis, and urticaria compared to the healthy control groups. The underlying factors of this relationship could be inflammation, psychological factors, hormonal changes, sleep disorders, sexual behavior-related allergic reactions, social economic status, and the use of medications.
SD and allergic disease are interrelated based on the extant literature. This scoping review provides insights into the clinical implications of both entities, while more research studies are warranted to further elucidate this complex relationship.
性障碍（SD）和过敏疾病是全球常见的健康问题，二者可能存在关联。本范围性综述旨在分析目前有关这两种健康问题之间关联的现有数据。
在 PubMed、MEDLINE、Embase、Cochrane 对照试验中心注册库（CENTRAL）和 Web of Science 数据库中进行全面的文献检索，以检索 2023 年 1 月之前发表的研究。根据女性性功能指数（FSFI）和国际勃起功能指数（IIEF）的评估，进行叙述性综合分析，以探讨过敏疾病对 SD 的影响。
经过筛选过程，共纳入了 12 项观察性研究。结果普遍表明，与健康对照组相比，哮喘、过敏性鼻炎、过敏性鼻结膜炎和荨麻疹患者的 FSFI 或 IIEF 评分较低。这种关系的潜在因素可能是炎症、心理因素、激素变化、睡眠障碍、与性行为相关的过敏反应、社会经济地位和药物使用。
基于现有文献，SD 和过敏疾病是相互关联的。本范围性综述提供了对这两种疾病的临床意义的深入了解，同时需要更多的研究来进一步阐明这种复杂的关系。
