Li Peng, Meng Zhaotun, Lin Liqiang, Chen Zhipeng, Lv Huaiqing
School of Clinical Medicine, Shandong Second Medical University, Weifang, China.
Department of Otorhinolaryngology, Linyi People's Hospital, Linyi, China.
Front Genet. 2024 Jul 24;15:1423357. doi: 10.3389/fgene.2024.1423357. eCollection 2024.
Evidence shows that allergic rhinitis (AR) may increase the risk of erectile dysfunction (ED). This study aims to investigate whether there is a causal relationship between AAR and ED by Mendelian randomization (MR) analysis.
We performed a two-sample MR analysis using genome-wide association studies (GWAS) summary data. Single nucleotide polymorphisms (SNPs) associated with AR and ED were obtained from the GWAS database. The MR analysis primarily employed the inverse variance weighted (IVW), MR Egger, and weighted median (WM) methods. We assessed pleiotropy using the MR-PRESSO global test and MR-Egger regression. Cochran's Q test was used to evaluate heterogeneity, and a leave-one-out analysis was performed to verify the robustness and reliability of the results.
The IVW analysis demonstrated a positive association between genetic susceptibility to AR and an elevated relative risk of ED (IVW OR = 1.40, = 0.01, 95% CI 1.08-1.80). The results obtained from MR-Egger regression and WM methods exhibited a consistent trend with the results of the IVW method. Sensitivity analyses showed no evidence of heterogeneity nor horizontal pleiotropy. The leave-one-out analysis showed that the findings remained robust and were unaffected by any instrumental variables.
This study presents genetic evidence that indicates a causal association between AR and ED.
有证据表明过敏性鼻炎（AR）可能会增加勃起功能障碍（ED）的风险。本研究旨在通过孟德尔随机化（MR）分析来探究AR与ED之间是否存在因果关系。
我们使用全基因组关联研究（GWAS）汇总数据进行了两样本MR分析。与AR和ED相关的单核苷酸多态性（SNP）是从GWAS数据库中获取的。MR分析主要采用逆方差加权（IVW）、MR Egger和加权中位数（WM）方法。我们使用MR-PRESSO全局检验和MR-Egger回归评估多效性。使用 Cochr an's Q检验评估异质性，并进行留一法分析以验证结果的稳健性和可靠性。
IVW分析表明，AR的遗传易感性与ED相对风险升高之间存在正相关（IVW比值比 = 1.40，P = 0.01，95%置信区间1.08 - 1.80）。MR-Egger回归和WM方法得到的结果与IVW方法的结果呈现出一致的趋势。敏感性分析未发现异质性或水平多效性的证据。留一法分析表明，研究结果仍然稳健，不受任何工具变量的影响。
本研究提供了遗传证据，表明AR与ED之间存在因果关联。
