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Cytotoxic activity of essential oil from Leaves of Myrcia splendens against A549 Lung Cancer cells.灿烂桃金娘叶挥发油对 A549 肺癌细胞的细胞毒性作用。
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Reversing Multidrug Resistance in Chemo-resistant Human Lung Adenocarcinoma (A549/DOX) Cells by Algerian Propolis Through Direct Inhibiting the P-gp Efflux-pump, G0/G1 Cell Cycle Arrest and Apoptosis Induction.阿尔及利亚蜂胶通过直接抑制P-糖蛋白外排泵、诱导G0/G1期细胞周期阻滞和凋亡来逆转人肺腺癌化疗耐药细胞（A549/DOX）的多药耐药性
Anticancer Agents Med Chem. 2018;18(9):1330-1337. doi: 10.2174/1871520618666180808100800.
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Novel tetrahydroacridine derivatives with iodobenzoic moieties induce G0/G1 cell cycle arrest and apoptosis in A549 non-small lung cancer and HT-29 colorectal cancer cells.具有碘代苯甲酸部分的新型四氢吖啶衍生物诱导 A549 非小细胞肺癌和 HT-29 结肠癌细胞的 G0/G1 细胞周期停滞和细胞凋亡。
Mol Cell Biochem. 2019 Oct;460(1-2):123-150. doi: 10.1007/s11010-019-03576-x. Epub 2019 Jul 16.
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Antineoplastic effects of deoxyelephantopin, a sesquiterpene lactone from Elephantopus scaber, on lung adenocarcinoma (A549) cells.地胆草倍半萜内酯脱氧土大黄素对肺腺癌细胞（A549）的抗肿瘤作用。
J Integr Med. 2013 Jul;11(4):269-77. doi: 10.3736/jintegrmed2013040.
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[Synergistic Antitumor Effect of Amorphigenin Combined with Cisplatin in Human Lung Adenocarcinoma A549/DDP Cells].[知母皂苷元联合顺铂对人肺腺癌A549/DDP细胞的协同抗肿瘤作用]
Zhongguo Fei Ai Za Zhi. 2016 Dec 20;19(12):805-812. doi: 10.3779/j.issn.1009-3419.2016.12.02.
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XPC inhibition rescues cisplatin resistance via the Akt/mTOR signaling pathway in A549/DDP lung adenocarcinoma cells.XPC 抑制通过 Akt/mTOR 信号通路拯救 A549/DDP 肺腺癌细胞中的顺铂耐药性。
Oncol Rep. 2019 Mar;41(3):1875-1882. doi: 10.3892/or.2019.6959. Epub 2019 Jan 9.
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A milbemycin compound isolated from Streptomyces Sp. FJS31-2 with cytotoxicity and reversal of cisplatin resistance activity in A549/DDP cells.从链霉菌属 FJS31-2 中分离得到的米尔贝霉素化合物具有细胞毒性，并能逆转 A549/DDP 细胞中的顺铂耐药性。
Biomed Pharmacother. 2020 Aug;128:110322. doi: 10.1016/j.biopha.2020.110322. Epub 2020 Jun 4.
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Phosphoinositide specific phospholipase Cγ1 inhibition-driven autophagy caused cell death in human lung adenocarcinoma A549 cells and .磷酸肌醇特异性磷脂酶 Cγ1 抑制诱导的自噬导致人肺腺癌细胞 A549 死亡。
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本文引用的文献
1
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.《全球癌症统计数据 2020：全球 185 个国家和地区 36 种癌症的发病率和死亡率估计》。
CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
2
Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019.天然产物：1981 年 1 月至 2019 年 9 月近四十年来的新药来源
J Nat Prod. 2020 Mar 27;83(3):770-803. doi: 10.1021/acs.jnatprod.9b01285. Epub 2020 Mar 12.
3
Synthesis and cytotoxicity evaluation of glycosidic derivatives of lawsone against breast cancer cell lines.合成并评价了洛索洛芬糖基衍生物对乳腺癌细胞系的细胞毒性。
Bioorg Med Chem Lett. 2020 Jan 15;30(2):126817. doi: 10.1016/j.bmcl.2019.126817. Epub 2019 Nov 16.
4
Targeting cathepsin K diminishes prostate cancer establishment and growth in murine bone.靶向组织蛋白酶 K 可减少鼠骨中前列腺癌的建立和生长。
J Cancer Res Clin Oncol. 2019 Aug;145(8):1999-2012. doi: 10.1007/s00432-019-02950-y. Epub 2019 Jun 6.
5
The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K.炔基部分作为半胱氨酸蛋白酶 K 不可逆共价小分子抑制剂中的潜伏亲电试剂。
J Am Chem Soc. 2019 Feb 27;141(8):3507-3514. doi: 10.1021/jacs.8b11027. Epub 2019 Feb 14.
6
Lawsone derivatives target the Wnt/β-catenin signaling pathway in multidrug-resistant acute lymphoblastic leukemia cells.胡桃醌衍生物靶向多药耐药急性淋巴细胞白血病细胞中的Wnt/β-连环蛋白信号通路。
Biochem Pharmacol. 2017 Dec 15;146:63-73. doi: 10.1016/j.bcp.2017.10.008. Epub 2017 Oct 20.
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Antinflammatory and anticancer effects of terpenes from oily fractions of Teucruim alopecurus, blocker of IκBα kinase, through downregulation of NF-κB activation, potentiation of apoptosis and suppression of NF-κB-regulated gene expression.筋骨草中挥发油萜类成分通过抑制 IκBα 激酶、NF-κB 激活下调、促进凋亡和抑制 NF-κB 调控基因表达而发挥抗炎和抗癌作用。
Biomed Pharmacother. 2017 Nov;95:1876-1885. doi: 10.1016/j.biopha.2017.09.115. Epub 2017 Oct 6.
8
Selective Ru(II)/lawsone complexes inhibiting tumor cell growth by apoptosis.通过凋亡抑制肿瘤细胞生长的选择性钌（II）/胡桃醌配合物
J Inorg Biochem. 2017 Nov;176:66-76. doi: 10.1016/j.jinorgbio.2017.08.019. Epub 2017 Aug 26.
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In vitro and in vivo antifungal efficacy of plant based lawsone against Fusarium oxysporum species complex.基于植物的胡桃醌对尖孢镰刀菌复合种的体外和体内抗真菌功效
Microbiol Res. 2017 Aug;201:21-29. doi: 10.1016/j.micres.2017.04.011. Epub 2017 Apr 30.
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Mechanistic study on lung cancer mortality after radon exposure in the Wismut cohort supports important role of clonal expansion in lung carcinogenesis.对维斯穆特队列中氡暴露后肺癌死亡率的机制研究支持了克隆扩增在肺癌发生中的重要作用。
Radiat Environ Biophys. 2016 Aug;55(3):299-315. doi: 10.1007/s00411-016-0659-0. Epub 2016 Jun 22.
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