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慢性肌炎患者的骨骼肌纤维可产生 B 细胞刺激因子。

Skeletal muscle fibers produce B-cell stimulatory factors in chronic myositis.

机构信息

Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.

Institute of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.

出版信息

Front Immunol. 2023 Sep 5;14:1177721. doi: 10.3389/fimmu.2023.1177721. eCollection 2023.

DOI:10.3389/fimmu.2023.1177721
PMID:37731487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10508232/
Abstract

INTRODUCTION

We aimed to identify B-cell-mediated immunomechanisms in inclusion body myositis (IBM) and polymyositis (PM) as part of the complex pathophysiology.

MATERIALS AND METHODS

Human primary myotube cultures were derived from orthopedic surgery. Diagnostic biopsy specimens from patients with IBM (n=9) and PM (n=9) were analyzed for markers of B cell activation (BAFF and APRIL) and for chemokines that control the recruitment of B cells (CXCL-12 and CXCL-13). Results were compared to biopsy specimens without myopathic changes (n=9) and hereditary muscular dystrophy (n=9).

RESULTS

The mRNA expression of BAFF, APRIL, and CXCL-13 was significantly higher in IBM and PM compared to controls. Patients with IBM displayed the highest number of double positive muscle fibers for BAFF and CXCL-12 (48%) compared to PM (25%), muscular dystrophy (3%), and non-myopathic controls (0%). , exposure of human myotubes to pro-inflammatory cytokines led to a significant upregulation of BAFF and CXCL-12, but APRIL and CXCL-13 remained unchanged.

CONCLUSION

The results substantiate the hypothesis of an involvement of B cell-associated mechanisms in the pathophysiology of IBM and PM. Muscle fibers themselves seem to contribute to the recruitment of B cells and sustain inflammation.

摘要

简介

我们旨在确定包涵体肌炎 (IBM) 和多发性肌炎 (PM) 中的 B 细胞介导的免疫机制，作为复杂病理生理学的一部分。

材料和方法

从矫形外科手术中获得人类原代肌管培养物。分析来自 IBM（n=9）和 PM（n=9）患者的诊断性活检标本中 B 细胞激活标志物（BAFF 和 APRIL）以及控制 B 细胞募集的趋化因子（CXCL-12 和 CXCL-13）。将结果与无肌病变化的活检标本（n=9）和遗传性肌肉营养不良（n=9）进行比较。

结果

与对照组相比，BAFF、APRIL 和 CXCL-13 的 mRNA 表达在 IBM 和 PM 中明显更高。与 PM（25%）、肌肉营养不良（3%）和非肌病对照组（0%）相比，IBM 患者显示出最多的 BAFF 和 CXCL-12 双阳性肌纤维（48%）。此外，体外向人类肌管暴露于促炎细胞因子会导致 BAFF 和 CXCL-12 的显著上调，但 APRIL 和 CXCL-13 保持不变。

结论

这些结果证实了 B 细胞相关机制参与 IBM 和 PM 病理生理学的假设。肌纤维本身似乎有助于 B 细胞的募集并维持炎症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd84/10508232/e17d2b304003/fimmu-14-1177721-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd84/10508232/93244f401280/fimmu-14-1177721-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd84/10508232/4734891a7f99/fimmu-14-1177721-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd84/10508232/9672cea8ca7e/fimmu-14-1177721-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd84/10508232/e17d2b304003/fimmu-14-1177721-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd84/10508232/93244f401280/fimmu-14-1177721-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd84/10508232/4734891a7f99/fimmu-14-1177721-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd84/10508232/9672cea8ca7e/fimmu-14-1177721-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd84/10508232/e17d2b304003/fimmu-14-1177721-g004.jpg

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2
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Acta Pharmacol Sin. 2021 Oct;42(10):1665-1675. doi: 10.1038/s41401-020-00582-4. Epub 2021 Jan 22.
3
Jo-1 autoantigen-specific B cells are skewed towards distinct functional B cell subsets in anti-synthetase syndrome patients.
Clin Rev Allergy Immunol. 2025 Apr 10;68(1):40. doi: 10.1007/s12016-025-09047-0.
4
Successful treatment of anti-signal recognition particle antibody-positive myositis with intravenous cyclophosphamide: A case report.静脉注射环磷酰胺成功治疗抗信号识别颗粒抗体阳性肌炎：一例报告
Fukushima J Med Sci. 2025 Jan 18;71(1):63-68. doi: 10.5387/fms.24-00013. Epub 2024 Dec 7.
5
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J Immunol. 2024 Apr 15;212(8):1287-1306. doi: 10.4049/jimmunol.2300841.
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Arthritis Res Ther. 2021 Jan 19;23(1):33. doi: 10.1186/s13075-020-02412-8.
4
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