日本患者接种新冠疫苗后出现的长期新冠症状
Longitudinal long COVID symptoms in Japanese patients after COVID-19 vaccinations.
作者信息
Nakagawara Kensuke, Morita Atsuho, Namkoong Ho, Terai Hideki, Chubachi Shotaro, Asakura Takanori, Tanaka Hiromu, Ito Fumimaro, Matsuyama Emiko, Kaji Masanori, Saito Ayaka, Takaoka Hatsuyo, Okada Masahiko, Sunata Keeya, Watase Mayuko, Yagi Kazuma, Ohgino Keiko, Miyata Jun, Kamata Hirofumi, Kawada Ichiro, Kobayashi Keigo, Hirano Toshiyuki, Inoue Takashi, Kagyo Junko, Shiomi Tetsuya, Otsuka Kengo, Miyao Naoki, Odani Toshio, Baba Rie, Arai Daisuke, Nakachi Ichiro, Ueda Soichiro, Funatsu Yohei, Koh Hidefumi, Ishioka Kota, Takahashi Saeko, Nakamura Morio, Sato Toshiro, Hasegawa Naoki, Kitagawa Yuko, Kanai Takanori, Ishii Makoto, Fukunaga Koichi
机构信息
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.
出版信息
Vaccine X. 2023 Sep 1;15:100381. doi: 10.1016/j.jvacx.2023.100381. eCollection 2023 Dec.
We conducted a subgroup analysis of a study on the long-term effects of COVID-19 (long COVID) in Japan to assess the effect of vaccination on long COVID symptoms. We assessed the clinical course of 111 patients with long COVID at the time of vaccination. The follow-up period was one year from the onset of COVID-19 or until the administration of the third vaccine dose. Of the 111 patients, 15 (13.5%) reported improvement, four (3.6%) reported deterioration, and 92 (82.9%) reported no change in their long COVID symptoms after vaccination. The most common long COVID symptoms before vaccination were alopecia, dyspnea, muscle weakness, fatigue, and headache among participants whose symptoms improved. Reduced dyspnea and alopecia were the most frequently reported improvements in symptoms after vaccination. Some symptoms persisted, including sleep disturbance, myalgia, and hypersensitivity. Vaccination did not appear to have a clinically important effect on patients with long COVID symptoms.
我们对一项关于新冠病毒长期影响（长新冠）的日本研究进行了亚组分析，以评估疫苗接种对长新冠症状的影响。我们评估了111例长新冠患者在接种疫苗时的临床病程。随访期为自新冠病毒感染发病起一年或直至接种第三剂疫苗。111例患者中，15例（13.5%）报告症状改善，4例（3.6%）报告症状恶化，92例（82.9%）报告接种疫苗后长新冠症状无变化。在症状改善的参与者中，接种疫苗前最常见的长新冠症状是脱发、呼吸困难、肌肉无力、疲劳和头痛。接种疫苗后症状改善最常报告的是呼吸困难减轻和脱发。一些症状持续存在，包括睡眠障碍、肌痛和过敏。疫苗接种似乎对有长新冠症状的患者没有临床重要影响。
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