子宫和卵巢中与子宫内膜异位症相关的鳞状细胞癌：一例报告。
Squamous cell carcinoma associated with endometriosis in the uterus and ovaries: A case report.
作者信息
Cai Zhe, Yang Gao-Liang, Li Qing, Zeng Lei, Li Li-Xiang, Song Yi-Pei, Liu Fan-Rong
机构信息
Department of Pathology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
Medical Imagine Center, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
出版信息
World J Clin Cases. 2023 Sep 16;11(26):6240-6245. doi: 10.12998/wjcc.v11.i26.6240.
BACKGROUND
Endometriosis is a common benign gynecological disease that causes dysmenorrhea in women of childbearing age. Malignant tumors derived from endometriosis are rarely reported and are found in only 1% of all patients with endometriosis. Here, we report a well-differentiated squamous cell carcinoma (SCC) caused by squamous metaplasia of endometriosis that co-occurred in the uterus and ovaries.
CASE SUMMARY
A 57-year-old postmenopausal woman had a 6-month history of irregular uterine bleeding. The uterus and adnexa were examined by computed tomography, and there were two solid cystic masses in the pelvis and right adnexa. Histological findings of surgical specimens showed well-differentiated SCC arising from squamous metaplasia of ectopic endometrial glands in the uterus and ovaries. The patient received chemotherapy after surgery and was followed up for 3 mo without metastasis.
CONCLUSION
The continuity between ectopic endometrial glands and SCC supports that SCC originates from ectopic endometrial glands with metaplasia towards squamous epithelium.
背景
子宫内膜异位症是一种常见的良性妇科疾病，可导致育龄期女性痛经。源自子宫内膜异位症的恶性肿瘤鲜有报道，仅在所有子宫内膜异位症患者中占1%。在此，我们报告一例由子宫内膜异位症的鳞状化生引起的高分化鳞状细胞癌，该肿瘤同时发生于子宫和卵巢。
病例摘要
一名57岁绝经后女性有6个月不规则子宫出血病史。通过计算机断层扫描检查子宫和附件，盆腔和右附件有两个实性囊性肿块。手术标本的组织学检查结果显示，子宫和卵巢中异位子宫内膜腺体的鳞状化生产生了高分化鳞状细胞癌。患者术后接受化疗，随访3个月无转移。
结论
异位子宫内膜腺体与鳞状细胞癌之间的连续性支持鳞状细胞癌起源于向鳞状上皮化生的异位子宫内膜腺体。
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