Qi Luyue, Zhang Zhenlin, Hu Weiwei
Shanghai Clinical Research Center of Bone Diseases, Department of Osteoporosis and Bone Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Arch Med Sci. 2023 Aug 25;19(5):1541-1544. doi: 10.5114/aoms/170851. eCollection 2023.
This study aimed to investigate the relationship of gene polymorphisms and fat mass (FM) in Chinese population.
Healthy males, premenopausal and postmenopausal women were recruited. Single Nucleotide Polymorphisms (SNPs) and FM were measured.
The rs141206415 in the RASAL1 gene and rs144493374 in the PALLD gene were associated with trunk FM, and the rs4807023 in the PTPRS gene was associated with leg FM using Spearman correlation analysis.
The results suggest that the RASAL1 gene and the PALLD gene might contribute to variability of trunk FM in healthy Chinese Han people. The PTPRS gene is potentially correlated with leg FM. Our findings provide a clue in fat metabolism.
本研究旨在调查中国人群中基因多态性与脂肪量（FM）之间的关系。
招募健康男性、绝经前和绝经后女性。测量单核苷酸多态性（SNP）和FM。
使用Spearman相关性分析，RASAL1基因中的rs141206415和PALLD基因中的rs144493374与躯干FM相关，PTPRS基因中的rs4807023与腿部FM相关。
结果表明，RASAL1基因和PALLD基因可能导致健康中国汉族人群躯干FM的变异性。PTPRS基因可能与腿部FM相关。我们的发现为脂肪代谢提供了线索。
