Klisic Aleksandra, Radoman Vujacic Irena, Munjas Jelena, Ninic Ana, Kotur-Stevuljevic Jelena
Primary Health Care Center, Faculty of Medicine, University of Montenegro, Podgorica, Montenegro.
Clinical Center of Montenegro, Department of Internal Medicine, Faculty of Medicine, University of Montenegro, Podgorica, Montenegro.
Arch Med Sci. 2022 Apr 10;18(4):870-880. doi: 10.5114/aoms/146796. eCollection 2022.
In parallel with the rapid growth of obesity, there is also an increase in the prevalence of type 2 diabetes mellitus (T2D) worldwide. Due to its complications, cardiovascular diseases are the leading cause of death in those patients. In the last two decades, special attention has been given to oxidative stress and inflammation, as the underlying mechanisms related to T2D occurrence and progression. Moreover, micro-ribonucleic acids (miRNAs) as new genetic biomarkers take an important place in the investigation of different metabolic pathways of insulin signaling. In this review article, we discuss microRNA modulation with oxidative stress and inflammation in patients with T2D. Better insight into the novel potential therapeutic targets for treatment of diabetes and its complications is of utmost importance for public health.
随着肥胖症的迅速增长，全球2型糖尿病（T2D）的患病率也在上升。由于其并发症，心血管疾病是这些患者的主要死因。在过去二十年中，氧化应激和炎症作为与T2D发生和发展相关的潜在机制受到了特别关注。此外，微小核糖核酸（miRNA）作为新的遗传生物标志物在胰岛素信号不同代谢途径的研究中占据重要地位。在这篇综述文章中，我们讨论了T2D患者中氧化应激和炎症对微小RNA的调节作用。更好地了解糖尿病及其并发症的新型潜在治疗靶点对公共卫生至关重要。
