2型糖尿病患者中氧化应激和炎症相关的微小核糖核酸调节——一篇综述文章
Micro-ribonucleic acid modulation with oxidative stress and inflammation in patients with type 2 diabetes mellitus - a review article.
作者信息
Klisic Aleksandra, Radoman Vujacic Irena, Munjas Jelena, Ninic Ana, Kotur-Stevuljevic Jelena
机构信息
Primary Health Care Center, Faculty of Medicine, University of Montenegro, Podgorica, Montenegro.
Clinical Center of Montenegro, Department of Internal Medicine, Faculty of Medicine, University of Montenegro, Podgorica, Montenegro.
出版信息
Arch Med Sci. 2022 Apr 10;18(4):870-880. doi: 10.5114/aoms/146796. eCollection 2022.
Abstract
In parallel with the rapid growth of obesity, there is also an increase in the prevalence of type 2 diabetes mellitus (T2D) worldwide. Due to its complications, cardiovascular diseases are the leading cause of death in those patients. In the last two decades, special attention has been given to oxidative stress and inflammation, as the underlying mechanisms related to T2D occurrence and progression. Moreover, micro-ribonucleic acids (miRNAs) as new genetic biomarkers take an important place in the investigation of different metabolic pathways of insulin signaling. In this review article, we discuss microRNA modulation with oxidative stress and inflammation in patients with T2D. Better insight into the novel potential therapeutic targets for treatment of diabetes and its complications is of utmost importance for public health.
摘要
随着肥胖症的迅速增长，全球2型糖尿病（T2D）的患病率也在上升。由于其并发症，心血管疾病是这些患者的主要死因。在过去二十年中，氧化应激和炎症作为与T2D发生和发展相关的潜在机制受到了特别关注。此外，微小核糖核酸（miRNA）作为新的遗传生物标志物在胰岛素信号不同代谢途径的研究中占据重要地位。在这篇综述文章中，我们讨论了T2D患者中氧化应激和炎症对微小RNA的调节作用。更好地了解糖尿病及其并发症的新型潜在治疗靶点对公共卫生至关重要。
相似文献
1
Micro-ribonucleic acid modulation with oxidative stress and inflammation in patients with type 2 diabetes mellitus - a review article.2型糖尿病患者中氧化应激和炎症相关的微小核糖核酸调节——一篇综述文章
Arch Med Sci. 2022 Apr 10;18(4):870-880. doi: 10.5114/aoms/146796. eCollection 2022.
2
The Correlation Between MicroRNAs and Diabetic Retinopathy.miRNAs 与糖尿病视网膜病变的相关性。
Front Immunol. 2022 Jul 25;13:941982. doi: 10.3389/fimmu.2022.941982. eCollection 2022.
3
Mechanisms underlying the pathophysiology of type 2 diabetes: From risk factors to oxidative stress, metabolic dysfunction, and hyperglycemia.2 型糖尿病病理生理学的发病机制：从危险因素到氧化应激、代谢功能障碍和高血糖。
Mutat Res Genet Toxicol Environ Mutagen. 2022 Feb-Mar;874-875:503437. doi: 10.1016/j.mrgentox.2021.503437. Epub 2021 Dec 14.
4
Diabetes and branched-chain amino acids: What is the link?糖尿病与支链氨基酸：它们之间有何关联？
J Diabetes. 2018 May;10(5):350-352. doi: 10.1111/1753-0407.12645. Epub 2018 Feb 13.
5
Does microRNA Perturbation Control the Mechanisms Linking Obesity and Diabetes? Implications for Cardiovascular Risk.微小 RNA 干扰是否控制肥胖和糖尿病相关机制？对心血管风险的影响。
Int J Mol Sci. 2020 Dec 25;22(1):143. doi: 10.3390/ijms22010143.
6
Expert Group Consensus Opinion: Role of Anti-inflammatory Agents in the Management of Type-2 Diabetes (T2D).专家小组共识意见：抗炎药物在2型糖尿病（T2D）管理中的作用
J Assoc Physicians India. 2019 Dec;67(12):65-74.
7
Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links.2型糖尿病、氧化应激与炎症：探究其间联系
Int J Physiol Pathophysiol Pharmacol. 2019 Jun 15;11(3):45-63. eCollection 2019.
8
Protein Kinases Signaling in Pancreatic Beta-cells Death and Type 2 Diabetes.蛋白激酶信号在胰腺β细胞死亡和 2 型糖尿病中的作用。
Adv Exp Med Biol. 2021;1275:195-227. doi: 10.1007/978-3-030-49844-3_8.
9
Remote ischemic conditioning: A potential therapeutic strategy of type 2 diabetes.远程缺血预处理：2型糖尿病的一种潜在治疗策略。
Med Hypotheses. 2021 Jan;146:110409. doi: 10.1016/j.mehy.2020.110409. Epub 2020 Nov 23.
10
Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology.中年糖尿病女性和男性对阿尔茨海默病样病理表现出不同的易感性。
Mol Neurobiol. 2017 Oct;54(8):6471-6489. doi: 10.1007/s12035-016-0155-1. Epub 2016 Oct 11.
引用本文的文献
1
miR-27a-3p, miR-222-3p and miR-340-5p as indicators of the antioxidant response activation in gestational diabetes.miR-27a-3p、miR-222-3p和miR-340-5p作为妊娠期糖尿病抗氧化反应激活的指标。
Mol Biol Rep. 2025 Jul 1;52(1):661. doi: 10.1007/s11033-025-10778-8.
2
Trimetazidine Alleviates Bleomycin-Induced Pulmonary Fibrosis by Targeting the Long Noncoding RNA CBR3-AS1-Mediated miRNA-29 and Resistin-Like Molecule alpha 1: Deciphering a Novel Trifecta Role of LncRNA CBR3-AS1/miRNA-29/FIZZ1 Axis in Lung Fibrosis.曲美他嗪通过靶向长链非编码 RNA CBR3-AS1 介导的 miRNA-29 和抵抗素样分子 alpha 1 缓解博来霉素诱导的肺纤维化：揭示长链非编码 RNA CBR3-AS1/miRNA-29/FIZZ1 轴在肺纤维化中的三重作用机制。
Drug Des Devel Ther. 2024 Sep 5;18:3959-3986. doi: 10.2147/DDDT.S463626. eCollection 2024.
3
The Cardiac-Kidney-Liver (CKL) syndrome: the "real entity" of type 2 diabetes mellitus.心肾肝（CKL）综合征：2型糖尿病的“真实实体”。
Arch Med Sci. 2024 Jan 31;20(1):207-215. doi: 10.5114/aoms/183070. eCollection 2024.
4
Oxidative Stress, Atherogenic Dyslipidemia, and Cardiovascular Risk.氧化应激、致动脉粥样硬化性血脂异常与心血管风险。
Biomedicines. 2023 Oct 26;11(11):2897. doi: 10.3390/biomedicines11112897.
5
The Link between miRNAs and PCKS9 in Atherosclerosis.miRNAs 与动脉粥样硬化中 PCKS9 的关系。
Curr Med Chem. 2024;31(42):6926-6956. doi: 10.2174/0109298673262124231102042914.
6
Identification of gene polymorphisms associated with fat mass by genome-wide association study in Chinese people.通过全基因组关联研究在中国人群中鉴定与脂肪量相关的基因多态性。
Arch Med Sci. 2023 Aug 25;19(5):1541-1544. doi: 10.5114/aoms/170851. eCollection 2023.
7
Cardiac microRNAs: diagnostic and therapeutic potential.心脏微小RNA：诊断和治疗潜力
Arch Med Sci. 2023 Aug 25;19(5):1360-1381. doi: 10.5114/aoms/169775. eCollection 2023.
8
Childhood obesity, metabolic syndrome, and oxidative stress: microRNAs go on stage.儿童肥胖、代谢综合征与氧化应激：microRNAs 粉墨登场。
Rev Endocr Metab Disord. 2023 Dec;24(6):1147-1164. doi: 10.1007/s11154-023-09834-0. Epub 2023 Sep 6.
本文引用的文献
1
Serum soluble transferrin receptor levels are independently associated with homeostasis model assessment of insulin resistance in adolescent girls.血清可溶性转铁蛋白受体水平与青春期女孩胰岛素抵抗的稳态模型评估独立相关。
Arch Med Sci. 2021 May 10;19(4):987-994. doi: 10.5114/aoms/132757. eCollection 2023.
2
Clinical value of microRNA-19a-3p and microRNA-99a-5p in bladder cancer.微小RNA-19a-3p和微小RNA-99a-5p在膀胱癌中的临床价值
Arch Med Sci. 2020 Oct 13;19(3):694-702. doi: 10.5114/aoms.2019.89700. eCollection 2023.
3
Oxidative stress and cardiometabolic biomarkers in patients with non-alcoholic fatty liver disease.非酒精性脂肪性肝病患者的氧化应激与心脏代谢生物标志物。
Sci Rep. 2021 Sep 16;11(1):18455. doi: 10.1038/s41598-021-97686-6.
4
Vildagliptin, a dipeptidyl peptidase-4 inhibitor, attenuated endothelial dysfunction through miRNAs in diabetic rats.维格列汀，一种二肽基肽酶-4抑制剂，通过微小RNA减轻糖尿病大鼠的内皮功能障碍。
Arch Med Sci. 2019 Jul 12;17(5):1378-1387. doi: 10.5114/aoms.2019.86609. eCollection 2021.
5
Genetics of macrovascular complications in type 2 diabetes.2型糖尿病大血管并发症的遗传学
World J Diabetes. 2021 Aug 15;12(8):1200-1219. doi: 10.4239/wjd.v12.i8.1200.
6
Emerging roles of exosomal miRNAs in diabetes mellitus.外泌体 miRNAs 在糖尿病中的新兴作用。
Clin Transl Med. 2021 Jun;11(6):e468. doi: 10.1002/ctm2.468.
7
Circulating microRNA-122, microRNA-126-3p and microRNA-146a are associated with inflammation in patients with pre-diabetes and type 2 diabetes mellitus: A case control study.循环 microRNA-122、microRNA-126-3p 和 microRNA-146a 与前驱糖尿病和 2 型糖尿病患者的炎症相关：一项病例对照研究。
PLoS One. 2021 Jun 2;16(6):e0251697. doi: 10.1371/journal.pone.0251697. eCollection 2021.
8
MicroRNAs and Oxidative Stress: An Intriguing Crosstalk to Be Exploited in the Management of Type 2 Diabetes.微小RNA与氧化应激：在2型糖尿病管理中有待开发利用的一种有趣的相互作用
Antioxidants (Basel). 2021 May 19;10(5):802. doi: 10.3390/antiox10050802.
9
miR-96-5p: A potential diagnostic marker for gestational diabetes mellitus.miR-96-5p：妊娠期糖尿病的潜在诊断标志物。
Medicine (Baltimore). 2021 May 28;100(21):e25808. doi: 10.1097/MD.0000000000025808.
10
Factorial Analysis of the Cardiometabolic Risk Influence on Redox Status Components in Adult Population.成年人群中心血管代谢风险对氧化还原状态成分的影响的析因分析。
Oxid Med Cell Longev. 2021 Jan 27;2021:6661940. doi: 10.1155/2021/6661940. eCollection 2021.
Zotero 插件