Department of Pharmacy Practice, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Department of Population and Family Reproductive Health, School of Public Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
J Pregnancy. 2023 Sep 12;2023:4194443. doi: 10.1155/2023/4194443. eCollection 2023.
Hypertensive disorders in pregnancy (HDPs) are no longer seen as "transitory diseases cured by delivery." It accounts for up to 50% of maternal deaths. Information concerning HDPs is less in developing countries like Ghana. This study was conducted to find out the prevalence, awareness, risk factors, control, and the birth outcomes of HDPs. This was a retrospective cohort study conducted among pregnant women seeking care in selected health facilities in the Ashanti Region. Data on demographics, HDPs, and its associated birth outcomes were collected. Logistic regression models were used to examine the association of the independent variables with HDPs. The burden of HDPs was 37.2% among the 500 mothers enrolled with chronic hypertension superimposed with preeclampsia accounting for 17.6%, chronic hypertension, 10.2%, and preeclampsia 6.8% whilst gestational hypertension was 2.6%. It was observed that 44% (220) of the mothers had excellent knowledge on HDPs. Oral nifedipine and methyldopa were frequently used for HDP management, and it resulted in a significant reduction in HDP burden from 37.2% to 26.6%. Factors that influenced the increased risk of HDPs were grand multigravida (AOR = 4.53; CI = 1.42-14.42), family history of hypertension (AOR = 3.61; CI = 1.89-6.90), and the consumption of herbal preparations (AOR = 2.92; CI = 1.15-7.41) and alcohol (AOR = 4.10; CI = 1.34-12.62) during pregnancy. HDPs increased the risk of preterm delivery (AOR = 2.66; CI = 1.29-5.89), stillbirth (AOR = 12.47; CI = 2.72-57.24), and undergoing caesarean section (AOR = 1.70; CI = 1.10-2.61) amongst mothers during delivery. The burden of HDPs is high amongst pregnant mothers seeking care in selected facilities. There is the need for intensified campaign on HDPs in the Ashanti Region of Ghana.
妊娠高血压疾病(HDP)不再被视为“分娩治愈的短暂疾病”。它占产妇死亡人数的 50%。在加纳等发展中国家,关于 HDP 的信息较少。本研究旨在了解 HDP 的患病率、知晓率、危险因素、控制情况和母婴结局。这是一项在阿散蒂地区选定医疗机构就诊的孕妇中进行的回顾性队列研究。收集了人口统计学、HDP 及其相关母婴结局的数据。使用逻辑回归模型来检查自变量与 HDP 的关联。在纳入的 500 名母亲中,HDP 的负担为 37.2%,其中慢性高血压合并子痫前期占 17.6%,慢性高血压占 10.2%,子痫前期占 6.8%,妊娠期高血压占 2.6%。结果发现,44%(220 名)的母亲对 HDP 有很好的认识。硝苯地平口服和甲多巴常用于 HDP 治疗,这显著降低了 HDP 的负担,从 37.2%降至 26.6%。影响 HDP 风险增加的因素有:多胎妊娠(OR=4.53;95%CI=1.42-14.42)、高血压家族史(OR=3.61;95%CI=1.89-6.90)、孕期服用草药制剂(OR=2.92;95%CI=1.15-7.41)和酒精(OR=4.10;95%CI=1.34-12.62)。HDP 增加了早产(OR=2.66;95%CI=1.29-5.89)、死产(OR=12.47;95%CI=2.72-57.24)和剖宫产(OR=1.70;95%CI=1.10-2.61)的风险。在选定的医疗机构中,寻求医疗的孕妇 HDP 负担很高。加纳阿散蒂地区需要加强对 HDP 的宣传。