Liu Wu, Qaed Eskandar, Zhu Yuelin, Tian Wenzhang, Wang Yizhen, Kang Le, Ma Xiaodong, Tang Zeyao
Pharmacology Department, Dalian Medical University, Dalian, West Section 9, South Road of Lvshun, Dalian, Liaoning 116044, P. R. China.
State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, P. R. China.
Am J Chin Med. 2023;51(7):1751-1793. doi: 10.1142/S0192415X23500787. Epub 2023 Sep 21.
Emodin is a natural compound found in several traditional Chinese medicines, including and . Recent studies have shown that emodin exhibits potent anticancer effects against a variety of cancer types, including liver, breast, lung, and colon cancer. Emodin's anticancer effects are mediated through several mechanisms, including inhibition of cell proliferation, induction of apoptosis, and suppression of tumor angiogenesis and metastasis. In this review, we provide an overview of recent research progress and new perspectives on emodin's anticancer effect. We summarize the current understanding of the molecular mechanisms underlying emodin's anticancer activity, including its effects on signaling pathways such as the PI3K/Akt, MAPK, and NF-[Formula: see text]B pathways. We also discuss the potential of emodin as a therapeutic agent for cancer treatment, including its use in combination with conventional chemotherapeutic drugs and as a sensitizer for radiotherapy. Furthermore, we highlight recent advances in the development of emodin derivatives and their potential as novel anticancer agents. Finally, we discuss the challenges and opportunities for the translation of emodin's anticancer properties into clinical applications, including the need for further preclinical and clinical studies to evaluate its safety and efficacy. In conclusion, emodin represents a promising natural compound with potent anticancer properties, and its potential as a therapeutic agent for cancer treatment warrants further investigation. This review provides a comprehensive overview of the current research progress and new perspectives on emodin's anticancer effects, which may facilitate the development of novel therapeutic strategies for cancer treatment.
大黄素是一种存在于多种传统中药中的天然化合物，包括[此处缺失两种中药名称]。最近的研究表明，大黄素对多种癌症类型具有强大的抗癌作用，包括肝癌、乳腺癌、肺癌和结肠癌。大黄素的抗癌作用是通过多种机制介导的，包括抑制细胞增殖、诱导细胞凋亡以及抑制肿瘤血管生成和转移。在这篇综述中，我们概述了大黄素抗癌作用的最新研究进展和新观点。我们总结了目前对大黄素抗癌活性潜在分子机制的理解，包括其对PI3K/Akt、MAPK和NF-[公式：见原文]B等信号通路的影响。我们还讨论了大黄素作为癌症治疗药物的潜力，包括其与传统化疗药物联合使用以及作为放疗增敏剂的用途。此外，我们强调了大黄素衍生物开发的最新进展及其作为新型抗癌药物的潜力。最后，我们讨论了将大黄素的抗癌特性转化为临床应用所面临的挑战和机遇，包括需要进一步的临床前和临床研究来评估其安全性和有效性。总之，大黄素是一种具有强大抗癌特性的有前途的天然化合物，其作为癌症治疗药物的潜力值得进一步研究。这篇综述全面概述了大黄素抗癌作用的当前研究进展和新观点，这可能有助于开发新的癌症治疗策略。
