• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

鉴定丹参酮 I 为帽依赖性内切核酸酶抑制剂，具有广谱抗病毒作用。

Identification of tanshinone I as cap-dependent endonuclease inhibitor with broad-spectrum antiviral effect.

机构信息

State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences , Wuhan, China.

The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital) , Shenzhen, China.

出版信息

J Virol. 2023 Oct 31;97(10):e0079623. doi: 10.1128/jvi.00796-23. Epub 2023 Sep 21.

DOI:10.1128/jvi.00796-23
PMID:37732786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10617418/
Abstract

The spread of avian-borne, tick-borne, and rodent-borne pathogens has the potential to pose a serious threat to human health, and candidate vaccines as well as therapeutics for these pathogens are urgently needed. Tanshinones, especially tanshinone I, were identified as a cap-dependent endonuclease inhibitor with broad-spectrum antiviral effects on negative-stranded, segmented RNA viruses including bandavirus, orthomyxovirus, and arenavirus from natural products, implying an important resource of candidate antivirals from the traditional Chinese medicines. This study supplies novel candidate antivirals for the negative-stranded, segmented RNA virus and highlights the endonuclease involved in the cap-snatching process as a reliable broad-spectrum antiviral target.

摘要

禽源、蜱传和鼠源病原体的传播有可能对人类健康构成严重威胁，迫切需要针对这些病原体的候选疫苗和疗法。从天然产物中发现丹参酮，特别是丹参酮 I，是一种帽依赖性内切核酸酶抑制剂，对包括簿波病毒、正粘病毒和沙粒病毒在内的负链、分段 RNA 病毒具有广谱抗病毒作用，这意味着从传统中药中获得候选抗病毒药物的重要资源。本研究为负链、分段 RNA 病毒提供了新的候选抗病毒药物，并强调了参与帽捕捉过程的内切核酸酶作为可靠的广谱抗病毒靶标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a709/10617418/c964d381f6b8/jvi.00796-23.f009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a709/10617418/b7560c89779c/jvi.00796-23.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a709/10617418/2c0ddf4a598c/jvi.00796-23.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a709/10617418/1122331a4f0c/jvi.00796-23.f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a709/10617418/89f44e81d4bd/jvi.00796-23.f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a709/10617418/5622d9f1c763/jvi.00796-23.f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a709/10617418/245ce255ed3b/jvi.00796-23.f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a709/10617418/90268b36bbe5/jvi.00796-23.f007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a709/10617418/b3f66dcb5d49/jvi.00796-23.f008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a709/10617418/c964d381f6b8/jvi.00796-23.f009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a709/10617418/b7560c89779c/jvi.00796-23.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a709/10617418/2c0ddf4a598c/jvi.00796-23.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a709/10617418/1122331a4f0c/jvi.00796-23.f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a709/10617418/89f44e81d4bd/jvi.00796-23.f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a709/10617418/5622d9f1c763/jvi.00796-23.f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a709/10617418/245ce255ed3b/jvi.00796-23.f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a709/10617418/90268b36bbe5/jvi.00796-23.f007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a709/10617418/b3f66dcb5d49/jvi.00796-23.f008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a709/10617418/c964d381f6b8/jvi.00796-23.f009.jpg

相似文献

1
Identification of tanshinone I as cap-dependent endonuclease inhibitor with broad-spectrum antiviral effect.鉴定丹参酮 I 为帽依赖性内切核酸酶抑制剂，具有广谱抗病毒作用。
J Virol. 2023 Oct 31;97(10):e0079623. doi: 10.1128/jvi.00796-23. Epub 2023 Sep 21.
2
Structural and Biochemical Basis for Development of Diketo Acid Inhibitors Targeting the Cap-Snatching Endonuclease of the Ebinur Lake Virus (Order: ).针对伊宁市湖病毒（目：）的帽抢夺内切酶的二酮酸抑制剂的结构和生化基础。
J Virol. 2022 Apr 13;96(7):e0217321. doi: 10.1128/jvi.02173-21. Epub 2022 Mar 10.
3
Biochemical and structural studies reveal differences and commonalities among cap-snatching endonucleases from segmented negative-strand RNA viruses.生化和结构研究揭示了分段负链 RNA 病毒中的帽抢夺内切酶之间的差异和共性。
J Biol Chem. 2018 Dec 21;293(51):19686-19698. doi: 10.1074/jbc.RA118.004373. Epub 2018 Oct 22.
4
Bunyaviridae RNA polymerases (L-protein) have an N-terminal, influenza-like endonuclease domain, essential for viral cap-dependent transcription.布尼亚病毒科 RNA 聚合酶（L 蛋白）具有一个 N 端的、类似流感的内切核酸酶结构域，这对于病毒的依赖帽结构的转录是必需的。
PLoS Pathog. 2010 Sep 16;6(9):e1001101. doi: 10.1371/journal.ppat.1001101.
5
Structure and function of the Toscana virus cap-snatching endonuclease.Toscana 病毒帽端攫取内切酶的结构与功能。
Nucleic Acids Res. 2019 Nov 18;47(20):10914-10930. doi: 10.1093/nar/gkz838.
6
The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target.Cap 抢夺 SFTSV 内切酶结构域是抗病毒靶点。
Cell Rep. 2020 Jan 7;30(1):153-163.e5. doi: 10.1016/j.celrep.2019.12.020.
7
Screening and identification of Lassa virus endonuclease-targeting inhibitors from a fragment-based drug discovery library.基于片段的药物发现文库筛选和鉴定拉沙病毒内切酶靶向抑制剂。
Antiviral Res. 2022 Jan;197:105230. doi: 10.1016/j.antiviral.2021.105230. Epub 2021 Dec 26.
8
Diketo acids inhibit the cap-snatching endonuclease of several Bunyavirales.二酮酸抑制几种 Bunyavirales 的帽抢夺内切酶。
Antiviral Res. 2020 Nov;183:104947. doi: 10.1016/j.antiviral.2020.104947. Epub 2020 Sep 24.
9
Hantavirus RdRp Requires a Host Cell Factor for Cap Snatching.汉坦病毒 RdRp 需要宿主细胞因子进行帽状结构攫取。
J Virol. 2019 Feb 19;93(5). doi: 10.1128/JVI.02088-18. Print 2019 Mar 1.
10
The Cap-Snatching Mechanism of Bunyaviruses.布尼亚病毒的“抢帽”机制。
Trends Microbiol. 2020 Apr;28(4):293-303. doi: 10.1016/j.tim.2019.12.006. Epub 2020 Jan 13.

引用本文的文献

1
How Can Plant-Derived Natural Products and Plant Biotechnology Help Against Emerging Viruses?植物源天然产物和植物生物技术如何助力对抗新出现的病毒？
Int J Mol Sci. 2025 Jul 22;26(15):7046. doi: 10.3390/ijms26157046.
2
Phytochemical-mediated efferocytosis and autophagy in inflammation control.植物化学物质介导的胞葬作用和自噬在炎症控制中的作用
Cell Death Discov. 2024 Dec 18;10(1):493. doi: 10.1038/s41420-024-02254-2.
3
Heartland Virus Disease-An Underreported Emerging Infection.心脏地带病毒病——一种报告不足的新发感染病
Microorganisms. 2024 Jan 29;12(2):286. doi: 10.3390/microorganisms12020286.