Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Mol Biotechnol. 2024 Sep;66(9):2396-2414. doi: 10.1007/s12033-023-00875-z. Epub 2023 Sep 21.
Pancreatic cancer is a lethal, extremely aggressive gastrointestinal tumor with a poor prognosis and limited treatment alternatives. Disulfidptosis is a newly defined type of cell death with potential influence on cancer. Research on the association between disulfidptosis and pancreatic cancer is scarce. The expression data of disulfidptosis-related genes were downloaded from The Cancer Genome Atlas-Pancreatic Adenocarcinoma (TCGA). Disulfidptosis-related lncRNA signature (DRLS) was developed through the Cox and the least absolute shrinkage and selection operator (LASSO) analysis. Differences in enrichment functions, mutational landscape, immune microenvironment, and predicted therapeutic efficacy between high- and low-risk groups were assessed. Consensus clustering analysis was applied to identify the DRLS-related subtypes. Among 98 disulfidptosis-related lncRNAs, 5 lncRNAs were screened thus constructing a prognostic DRLS. DRLS showed high predictive accuracy and was an independent prognostic factor for pancreatic cancer. According to the risk scores calculated from the signature, samples were categorized into high- and low- risk groups. Overall, low-risk patients had a better prognosis, lower mutational occurrences, higher immune cell infiltration and more sensitivity to anti-tumor agents. The DRLS performed well in predicting prognosis and revealed intimate correlation with biological function, mutation status and immune infiltration landscape of pancreatic cancer, providing some insights for future research on the relationship between disulfidptosis and pancreatic cancer.
胰腺癌是一种致命的、极具侵袭性的胃肠道肿瘤，预后不良，治疗选择有限。二硫键凋亡是一种新定义的细胞死亡类型，可能对癌症有影响。关于二硫键凋亡与胰腺癌之间的关系的研究还很少。从癌症基因组图谱-胰腺腺癌（TCGA）下载了与二硫键凋亡相关的基因表达数据。通过 Cox 和最小绝对收缩和选择算子（LASSO）分析，开发了与二硫键凋亡相关的长非编码 RNA 特征（DRLS）。评估了高低风险组之间的富集功能、突变景观、免疫微环境和预测治疗效果的差异。应用共识聚类分析来识别 DRLS 相关的亚型。在 98 个与二硫键凋亡相关的长非编码 RNA 中，筛选出 5 个长非编码 RNA，从而构建了一个预后 DRLS。DRLS 显示出较高的预测准确性，是胰腺癌的独立预后因素。根据该特征计算的风险评分，样本被分为高风险组和低风险组。总的来说，低风险患者的预后更好，突变发生率更低，免疫细胞浸润更高，对抗肿瘤药物更敏感。DRLS 在预测预后方面表现良好，并与胰腺癌的生物学功能、突变状态和免疫浸润景观密切相关，为进一步研究二硫键凋亡与胰腺癌之间的关系提供了一些思路。
