Hata T, Kita T, Higashiguchi T, Ichida S
Jpn J Pharmacol. 1986 Aug;41(4):475-85. doi: 10.1254/jjp.41.475.
The cholinergic activities in SART (specific alternation of rhythm in temperature)-stressed (repeated cold-stressed) rats, which are diseased rats with vagotonic-type dysautonomia, were examined with the following results. A decreased content of total acetylcholine (T-ACh) and increased activities of choline acetyltransferase (CAT) and acetylcholinesterase (ACh) in the basal ganglia and an increase in the T-ACh content and decrease in the AChE activity in the duodenum of SART-stressed rats reached the respective plateaus on day 5 of stress, which were maintained thereafter. CAT activity, however, in the hypothalamus was activated most on day 2. These changes in SART-stressed rats were different from those in simple cold-stressed rats. Subdiaphragmatic vagotomy inhibited the appearance of the changes in the duodenum, but not those in the hypothalamus of SART-stressed rats. The sedative analgesic Neurotropin prevented all the changes in SART-stressed rats described above. These results suggest that cholinergic neurons may be activated in both the hypothalamus and basal ganglia of the brain of SART-stressed rats, and the characteristic peripheral changes of the cholinergic system in the duodenum of SART-stressed rats may be under the control of the parasympathetic center.
对患迷走神经紧张型自主神经失调病的大鼠（即反复冷应激的SART（体温节律特异性交替）应激大鼠）的胆碱能活性进行了检测，结果如下。SART应激大鼠基底神经节中总乙酰胆碱（T-ACh）含量降低，胆碱乙酰转移酶（CAT）和乙酰胆碱酯酶（AChE）活性升高，十二指肠中T-ACh含量升高而AChE活性降低，在应激第5天分别达到各自的稳定水平，并在此后维持。然而，下丘脑的CAT活性在第2天激活最为明显。SART应激大鼠的这些变化与单纯冷应激大鼠的不同。膈下迷走神经切断术抑制了SART应激大鼠十二指肠中变化的出现，但未抑制下丘脑的变化。镇静镇痛药神经妥乐平可防止上述SART应激大鼠的所有变化。这些结果表明，SART应激大鼠脑内的下丘脑和基底神经节中的胆碱能神经元可能被激活，SART应激大鼠十二指肠中胆碱能系统的特征性外周变化可能受副交感神经中枢的控制。
