Tanaka H, Kuwahara Y, Okabe S
Jpn J Pharmacol. 1986 Aug;41(4):545-9. doi: 10.1254/jjp.41.545.
Repeated administration of histamine X 2HCl (40 mg/kg X 4) significantly augmented mepirizole (200 mg/kg) or cysteamine (300 mg/kg)-induced duodenal and gastric lesions in rats within 6 hr. Most of the duodenal lesions were penetrating ulcers and were located over the entire duodenum. Gastric lesions were mainly located in the antrum adjacent to the duodenum. Indomethacin pretreatment did not significantly augment the duodenal lesions induced by mepirizole or cysteamine, but did augment the gastric lesions induced by these compounds.
重复给予组胺二盐酸盐（40毫克/千克×4次）在6小时内显著增强了美吡立唑（200毫克/千克）或半胱胺（300毫克/千克）诱导的大鼠十二指肠和胃部损伤。大多数十二指肠损伤为穿透性溃疡，遍布整个十二指肠。胃部损伤主要位于十二指肠附近的胃窦部。吲哚美辛预处理并未显著增强美吡立唑或半胱胺诱导的十二指肠损伤，但增强了这些化合物诱导的胃部损伤。
