接受抗癫痫药物治疗的患者血浆中1,25-二羟基维生素D水平高而25-羟基维生素D水平低。

High 1,25-dihydroxyvitamin D and low 25-hydroxyvitamin D concentrations in plasma in patients receiving antiepileptic drugs.

作者信息

Maeda K, Ikeda H

出版信息

Jpn J Psychiatry Neurol. 1986 Mar;40(1):57-60. doi: 10.1111/j.1440-1819.1986.tb01612.x.

DOI:10.1111/j.1440-1819.1986.tb01612.x

Abstract

Plasma 25-hydroxyvitamin D (25-OH D), 1,25-dihydroxyvitamin D (1,25-(OH)2 D) and parathyroid hormone (PTH) concentrations were determined in 30 outpatients receiving various antiepileptic drugs (AED). None of the patients exhibited high plasma PTH levels. The plasma 1,25-(OH)2 D levels were normal or high, although in a third of the patients the 25-OH D levels were reduced. There was a correlation between the 25-OH D and serum calcium levels. These findings suggest that the low plasma concentrations of 25-OH D, not 1,25-(OH)2 D, might play an important part in the occurrence of AED-induced disturbances of bone metabolism.

摘要

对30名正在接受各种抗癫痫药物（AED）治疗的门诊患者测定了血浆25-羟基维生素D（25-OH D）、1,25-二羟基维生素D（1,25-(OH)2 D）和甲状旁腺激素（PTH）的浓度。所有患者的血浆PTH水平均未升高。血浆1,25-(OH)2 D水平正常或升高，尽管三分之一的患者25-OH D水平降低。25-OH D与血清钙水平之间存在相关性。这些发现表明，血浆中25-OH D而非1,25-(OH)2 D的低浓度可能在AED诱导的骨代谢紊乱的发生中起重要作用。