Cui Jiaxin, Fang Pei, Bai Jianjun, Tan Lanhui, Wan Changxiu, Yu Liping
Nurs Res. 2023;72(6):E180-E190. doi: 10.1097/NNR.0000000000000687. Epub 2023 Sep 19.
Early palliative care (PC) has received more attention for improving health-related outcomes for advanced cancer patients in recent years, but the results of previous studies are inconsistent.
This study aimed to use meta-analysis and trial sequence analysis to evaluate the effect of early PC on health-related outcomes of advanced cancer patients.
All English publications were searched in PubMed, Web of Science, Embase, and the Cochrane Library from inception to March 2023, with a restriction that the study type was a randomized controlled trial.
The results showed that early PC positively affected quality of life, satisfaction with care, and symptom burden reduction. However, early PC had no significant effect on anxiety or survival. Trial sequence analysis results showed that the effect of early PC on the quality of life was stable.
This systematic review suggested that early PC could positively affect health-related outcomes for advanced cancer patients. Early PC can be used widely in clinical settings to improve health-related outcomes of advanced cancer. However, because of the trial sequence analysis results, further well-designed, clinical, randomized controlled trials with larger sample sizes are necessary to draw definitive conclusions.
近年来，早期姑息治疗（PC）在改善晚期癌症患者健康相关结局方面受到了更多关注，但以往研究结果并不一致。
本研究旨在运用荟萃分析和试验序贯分析来评估早期PC对晚期癌症患者健康相关结局的影响。
检索了从创刊至2023年3月期间PubMed、科学网、Embase和Cochrane图书馆中的所有英文出版物，纳入标准为研究类型为随机对照试验。
结果显示，早期PC对生活质量、护理满意度和减轻症状负担有积极影响。然而，早期PC对焦虑或生存无显著影响。试验序贯分析结果表明，早期PC对生活质量的影响是稳定的。
本系统评价提示，早期PC可对晚期癌症患者的健康相关结局产生积极影响。早期PC可在临床环境中广泛应用，以改善晚期癌症患者的健康相关结局。然而，鉴于试验序贯分析结果，有必要开展进一步设计良好、样本量更大的临床随机对照试验，以得出明确结论。
