环己烯酮萜烯 A-J：来自红树林相关真菌 Penicillium sp. N-5 的细胞毒性混合萜类化合物。
Cyclohexenoneterpenes A-J: Cytotoxic meroterpenoids from mangrove-associated fungus Penicillium sp. N-5.
机构信息
School of Chemistry, Sun Yat-sen University, Guangzhou, 510275, China.
School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.
出版信息
Phytochemistry. 2023 Nov;215:113868. doi: 10.1016/j.phytochem.2023.113868. Epub 2023 Sep 19.
Ten previously undescribed meroterpenoids, cyclohexenoneterpenes A-J (1-7, 18-20), together with 10 known analogues (8-17) were isolated from the mangrove-associated fungus Penicillium sp. N-5. Their structures were elucidated on the basis of extensive spectroscopic and mass spectrometric data. The absolute configurations of the undescribed compounds were assigned by electronic circular dichroism calculations, the modified Mosher's method, NMR calculations and DP4+ analysis. In the bioassay, compounds 10, 11, 15, and 20 exhibited cytotoxicities against SNB-19, MDA-MB-231, MDA-MB-435 and HCT-116 cell lines with IC values ranging from 1.4 to 19.1 μM.
从红树林相关真菌青霉属 N-5 中分离到了 10 个以前未描述的倍半萜类化合物，环己烯酮萜烯 A-J（1-7、18-20），以及 10 个已知类似物（8-17）。基于广泛的光谱和质谱数据确定了它们的结构。通过电子圆二色性计算、改进的 Mosher 法、NMR 计算和 DP4+分析确定了未描述化合物的绝对构型。在生物测定中，化合物 10、11、15 和 20 对 SNB-19、MDA-MB-231、MDA-MB-435 和 HCT-116 细胞系表现出细胞毒性，IC 值范围为 1.4 至 19.1 μM。
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