Senior D F, Gaskin J M, Hines S A, Buergelt C D, Harvey J W, Keefe T J
Lab Anim Sci. 1986 Oct;36(5):486-91.
To induce an experimental model of bacterial cystitis, ten preconditioned dogs underwent bladder irritation with a 0.1% alcoholic solution of salicylic acid followed in 24 hours by an intravesicular infusion of Proteus mirabilis. The dogs were observed for the following 14 days (five dogs) and 17 days (five dogs) and then euthanatized and necropsied. Tenesmus, dysuria, hematuria, and pollakiuria occurred in all dogs, but the severity of these signs diminished with time. The total white cell, neutrophil, and monocyte counts in the peripheral blood increased and urinalysis results were consistent with infection and severe inflammation. The infection persisted for the duration of the study, although the average quantitative bacterial count in urine progressively declined. No changes occurred in the measured clinical chemistry values. Severe inflammation was present on gross examination of the bladder and microscopic examination of the bladder, prostate, and renal pelvis. Less severe inflammation was present on microscopic examination of the urethra and ureter.
为诱导细菌性膀胱炎的实验模型，十只预处理过的犬先用0.1%的水杨酸酒精溶液进行膀胱刺激，24小时后膀胱内注入奇异变形杆菌。随后对这些犬进行了如下观察：接下来的14天（五只犬）和17天（五只犬），然后实施安乐死并进行尸检。所有犬均出现里急后重、排尿困难、血尿和尿频，但这些症状的严重程度随时间减轻。外周血中的白细胞、中性粒细胞和单核细胞总数增加，尿液分析结果与感染和严重炎症相符。尽管尿液中的平均细菌定量计数逐渐下降，但感染在研究期间持续存在。所测临床化学值未发生变化。膀胱大体检查以及膀胱、前列腺和肾盂的显微镜检查均显示存在严重炎症。尿道和输尿管的显微镜检查显示炎症较轻。
