Biegen Vanessa R, Slusser Peter G, Fischetti Anthony J, Geist Michael R
Animal Medical Center, 510 E 62nd St, New York, NY 10065, USA.
J Am Vet Med Assoc. 2013 Mar 15;242(6):798-802. doi: 10.2460/javma.242.6.798.
A 5-year-old female spayed mixed-breed dog was examined because of signs of persistent stranguria following treatment for urethral obstruction.
Radiographic, ultrasonographic, cystoscopic, and histologic findings were consistent with encrusted cystitis. Results of bacteriologic culture of urine and bladder wall biopsy samples indicated growth of Staphylococcus pseudintermedius. Treatment and Outcome-The dog was initially treated via IV administration of fluids, placement of an indwelling urinary catheter, lavage of the bladder with sterile saline (0.9% NaCl) solution, and administration of antimicrobial drugs and bethanechol (to improve voiding of urine from the bladder). Antimicrobial drugs were administered for 3 months, and a commercially available diet for dissolution of urinary calculi was fed. Clinical signs of encrusted cystitis gradually resolved during the 3 months after the initial examination. Results of urinalysis and abdominal ultrasonographic examination performed 4 months after the initial examination indicated resolution of the disease.
Encrusted cystitis is extremely rare in small animals and has previously only been associated with Corynebacterium spp infection of the urinary bladder. Resolution of encrusted cystitis has previously been achieved via surgical debridement of the bladder and treatment with antimicrobial drugs. The clinical findings and successful resolution of clinical signs in the dog of the present report suggested that urease-positive bacteria other than Corynebacterium spp can cause encrusted cystitis and that feeding of a diet for dissolution of urinary calculi in conjunction with antimicrobial treatment may result in resolution of urinary bladder lesions and clinical signs attributable to the disease without the need for surgical debridement of encrusted plaques.
一只5岁已绝育的混种雌性犬因尿道梗阻治疗后持续出现排尿困难的症状而接受检查。
放射学、超声学、膀胱镜检查及组织学检查结果均符合结痂性膀胱炎。尿液和膀胱壁活检样本的细菌培养结果显示有中间型假葡萄球菌生长。治疗与结果——该犬最初通过静脉输液、留置导尿管、用无菌生理盐水（0.9%氯化钠）溶液冲洗膀胱以及给予抗菌药物和氨甲酰甲胆碱（以促进膀胱排尿）进行治疗。抗菌药物使用了3个月，并喂食了一种市售的用于溶解尿路结石的日粮。在初次检查后的3个月内，结痂性膀胱炎的临床症状逐渐缓解。初次检查4个月后进行的尿液分析和腹部超声检查结果表明疾病已痊愈。
结痂性膀胱炎在小动物中极为罕见，此前仅与膀胱棒状杆菌属感染有关。此前结痂性膀胱炎的治愈是通过膀胱手术清创和抗菌药物治疗实现的。本报告中该犬的临床发现及临床症状的成功缓解表明，除棒状杆菌属外的脲酶阳性细菌也可导致结痂性膀胱炎，并且喂食用于溶解尿路结石的日粮并结合抗菌治疗可能会使膀胱病变及该疾病所致的临床症状得到缓解，而无需对结痂斑块进行手术清创。
