Bishop M J, Boatman E S, Webster R, Ivey T D, Cheney F W
J Surg Res. 1986 Oct;41(4):394-400. doi: 10.1016/0022-4804(86)90053-3.
We studied the effects of interruption of the pulmonary blood flow to the left diaphragmatic lung lobe on the evolution of canine oleic acid lung injury. We compared the morphology and edema of the left diaphragmatic lobe, whose pulmonary artery was ligated immediately after oleic acid injury, with the right diaphragmatic lobe, in which the blood supply was intact. The injury plus ligation resulted in hypoxemia and pulmonary hypertension with PaO2 falling from 98 +/- 4 to 72 +/- 21 torr (P less than 0.05) and pulmonary artery pressure increasing from 11 +/- 3 to 18 +/- 4 mm Hg (P less than 0.05). Animals were sacrificed 48 hr following the injury. Morphological examination of right and left lobes showed no consistent differences although wet/dry ratios indicated significantly greater edema (P less than 0.01) for the right diaphragmatic lobes (7.66 +/- 1.23) than the left (6.80 +/- 0.59). Both right and left lobes were substantially more edematous than our laboratory normal value of 4.74 +/- 0.54 (P less than 0.001 for both). We conclude that interruption of pulmonary arterial blood flow protects against edema formation in oleic acid injury but does not alter the morphologic evolution of the injury.
我们研究了阻断流向左膈叶肺的肺血流对犬油酸肺损伤进展的影响。我们将油酸损伤后立即结扎肺动脉的左膈叶的形态和水肿情况，与血供完好的右膈叶进行了比较。损伤加结扎导致低氧血症和肺动脉高压，动脉血氧分压从98±4降至72±21托（P<0.05），肺动脉压从11±3升至18±4毫米汞柱（P<0.05）。损伤后48小时处死动物。右叶和左叶的形态学检查未显示出一致的差异，尽管湿/干比表明右膈叶（7.66±1.23）的水肿明显大于左膈叶（6.80±0.59）（P<0.01）。右叶和左叶的水肿程度均明显高于我们实验室4.74±0.54的正常数值（两者P<0.001）。我们得出结论，阻断肺动脉血流可预防油酸损伤中水肿的形成，但不会改变损伤的形态学进展。
