Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, California, USA.
Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, California, USA.
Genesis. 2024 Feb;62(1):e23553. doi: 10.1002/dvg.23553. Epub 2023 Sep 21.
The neural crest is a stem cell population that originates from the ectoderm during the initial steps of nervous system development. Neural crest cells delaminate from the neuroepithelium by undergoing a spatiotemporally regulated epithelial-mesenchymal transition (EMT) that proceeds in a coordinated wave head-to-tail to exit from the neural tube. While much is known about the transcriptional programs and membrane changes that promote EMT, there are additional levels of gene expression control that neural crest cells exert at the level of RNA to control EMT and migration. Yet, the role of post-transcriptional regulation, and how it drives and contributes to neural crest EMT, is not well understood. In this mini-review, we explore recent advances in our understanding of the role of post-transcriptional regulation during neural crest EMT.
神经嵴是一种干细胞群体，起源于神经系统发育初期的外胚层。神经嵴细胞通过经历时空调节的上皮-间充质转化（EMT）从神经上皮细胞层分离出来，该转化以协调的头尾波的方式进行，从而从神经管中退出。虽然人们已经了解了促进 EMT 的转录程序和膜变化，但神经嵴细胞在 RNA 水平上还施加了其他水平的基因表达控制，以控制 EMT 和迁移。然而，转录后调控的作用以及它如何驱动和促进神经嵴 EMT 的作用还不是很清楚。在这篇迷你综述中，我们探讨了我们对神经嵴 EMT 过程中转录后调控作用的理解的最新进展。
