Laboratory of Cell-Based Assays and Innovations, School of Biotechnology, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
J Asian Nat Prod Res. 2024 May;26(5):583-603. doi: 10.1080/10286020.2023.2258797. Epub 2023 Sep 21.
Alzheimer's causes cognitive dysfunction. This study investigated the neuro-promoting effects of cordycepin on amyloid-beta precursor protein (APP) synthesis in human neuroblastoma SH-SY5Y cells. Cordycepin was found to boost SH-SY5Y cell proliferation and decreased AD pathology. APP, PS1, and PS2 were downregulated whereas and were upregulated by cordycepin. Cordycepin also reduced APP secretion in a dose-dependent manner. Cordycepin alleviated oxidative stress by the upregulation of and , as well as autophagy genes (, , and ). Cordycepin activity was also found to be SIRT1-dependent. Therefore, cordycepin may relieve the neuronal degeneration caused by APP overproduction, and oxidative stress.
阿尔茨海默病导致认知功能障碍。本研究探讨了蛹虫草素对人神经母细胞瘤 SH-SY5Y 细胞中淀粉样前体蛋白（APP）合成的神经促进作用。结果发现蛹虫草素有促进 SH-SY5Y 细胞增殖和减少 AD 病理的作用。蛹虫草素下调 APP、PS1 和 PS2 的表达，而上调 和 的表达。蛹虫草素还以剂量依赖的方式减少 APP 的分泌。蛹虫草素通过上调 和 以及自噬基因（ 、 和 ）来缓解氧化应激。还发现蛹虫草素的活性依赖于 SIRT1。因此，蛹虫草素可能缓解 APP 过度产生和氧化应激引起的神经元变性。
