Centre for Functional and Metabolic Mapping, Robarts Research Institute, The University of Western Ontario, London, ON N6A 5B7, Canada;
Centre for Functional and Metabolic Mapping, Robarts Research Institute, The University of Western Ontario, London, ON N6A 5B7, Canada.
Proc Natl Acad Sci U S A. 2021 Sep 14;118(37). doi: 10.1073/pnas.2110980118.
The common marmoset has enormous promise as a nonhuman primate model of human brain functions. While resting-state functional MRI (fMRI) has provided evidence for a similar organization of marmoset and human cortices, the technique cannot be used to map the functional correspondences of brain regions between species. This limitation can be overcome by movie-driven fMRI (md-fMRI), which has become a popular tool for noninvasively mapping the neural patterns generated by rich and naturalistic stimulation. Here, we used md-fMRI in marmosets and humans to identify whole-brain functional correspondences between the two primate species. In particular, we describe functional correlates for the well-known human face, body, and scene patches in marmosets. We find that these networks have a similar organization in both species, suggesting a largely conserved organization of higher-order visual areas between New World marmoset monkeys and humans. However, while face patches in humans and marmosets were activated by marmoset faces, only human face patches responded to the faces of other animals. Together, the results demonstrate that higher-order visual processing might be a conserved feature between humans and New World marmoset monkeys but that small, potentially important functional differences exist.
普通狨猴作为研究人类大脑功能的非人类灵长类动物模型具有巨大的潜力。虽然静息态功能磁共振成像（fMRI）为狨猴和人类大脑皮质的相似组织提供了证据，但该技术不能用于映射物种间大脑区域的功能对应关系。可以通过电影驱动 fMRI（md-fMRI）来克服这一局限性，该技术已成为一种流行的工具，可用于非侵入性地绘制由丰富和自然刺激产生的神经模式。在这里，我们在狨猴和人类中使用 md-fMRI 来确定这两种灵长类动物之间的全脑功能对应关系。特别是，我们描述了狨猴中众所周知的人脸、身体和场景补丁的功能相关性。我们发现这些网络在两种物种中具有相似的组织，这表明在新世界狨猴和人类之间，高级视觉区域的组织具有很大的保守性。然而，尽管人类和狨猴的面部斑块被狨猴的面部激活，但只有人类的面部斑块对其他动物的面部有反应。总之，这些结果表明，高级视觉处理可能是人类和新世界狨猴之间的一个保守特征，但存在一些小的、可能很重要的功能差异。
