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Low fixed dose pembrolizumab with gemcitabine, vinorelbine, liposomal doxorubicin (Pembro100 -GVD) as an effective salvage regimen in relapsed refractory classical hodgkin's lymphoma and primary mediastinal B cell lymphoma.

作者信息

Panda Tribikram, Rainchwar Sujay, Halder Rohan, Singh Reema, Bhurani Dinesh, Agrawal Narendra

机构信息

Department of Hemato-Oncology and Bone Marrow Transplant, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.

出版信息

Ann Hematol. 2024 Jan;103(1):347-349. doi: 10.1007/s00277-023-05470-5. Epub 2023 Sep 23.

DOI:10.1007/s00277-023-05470-5
PMID:37740065
Abstract
摘要

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Low fixed dose pembrolizumab with gemcitabine, vinorelbine, liposomal doxorubicin (Pembro100 -GVD) as an effective salvage regimen in relapsed refractory classical hodgkin's lymphoma and primary mediastinal B cell lymphoma.低固定剂量派姆单抗联合吉西他滨、长春瑞滨、脂质体阿霉素(Pembro100 - GVD)作为复发难治性经典型霍奇金淋巴瘤和原发性纵隔B细胞淋巴瘤的有效挽救方案。
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2
Promising long-term outcome of gemcitabine, vinorelbine, liposomal doxorubicin (GVD) in 14-day schedule as salvage regimen for patients with previously heavily treated Hodgkin's lymphoma and aggressive non-Hodgkin's lymphoma.吉西他滨、长春瑞滨、脂质体多柔比星(GVD)14 天方案作为挽救方案治疗既往大量治疗的霍奇金淋巴瘤和侵袭性非霍奇金淋巴瘤患者具有良好的长期疗效。
Med Oncol. 2013 Mar;30(1):350. doi: 10.1007/s12032-012-0350-5. Epub 2013 Jan 18.
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Ann Hematol. 2015 Aug;94(8):1401-6. doi: 10.1007/s00277-015-2362-7. Epub 2015 Apr 12.
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Combination of PD-1 inhibitor with GVD (gemcitabine, vinorelbine, liposomal doxorubicin) versus GVD regimen as second-line therapy for relapsed/refractory classical Hodgkin lymphoma.PD-1 抑制剂联合 GVD(吉西他滨、长春瑞滨、脂质体多柔比星)与 GVD 方案作为复发/难治性经典霍奇金淋巴瘤二线治疗的比较。
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Gemcitabine, vinorelbine, and pegylated liposomal doxorubicin (GVD), a salvage regimen in relapsed Hodgkin's lymphoma: CALGB 59804.吉西他滨、长春瑞滨和聚乙二醇化脂质体阿霉素(GVD),复发霍奇金淋巴瘤的挽救方案:癌症和白血病研究组B(CALGB)59804。
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Haematologica. 2007 Jan;92(1):35-41. doi: 10.3324/haematol.10661.

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Current Issues and Future Perspectives of Targeted Therapies in Primary Mediastinal Large B-Cell Lymphoma.原发性纵隔大B细胞淋巴瘤靶向治疗的当前问题与未来展望
J Clin Med. 2025 Feb 11;14(4):1191. doi: 10.3390/jcm14041191.

本文引用的文献

1
Pembrolizumab in relapsed or refractory primary mediastinal large B-cell lymphoma: final analysis of KEYNOTE-170.帕博利珠单抗治疗复发或难治性原发性纵隔大 B 细胞淋巴瘤:KEYNOTE-170 研究的最终分析。
Blood. 2023 Jul 13;142(2):141-145. doi: 10.1182/blood.2022019340.
2
Current and emerging treatment options in primary mediastinal B-cell lymphoma.原发性纵隔B细胞淋巴瘤的当前及新出现的治疗选择
Ther Adv Hematol. 2021 Oct 8;12:20406207211048959. doi: 10.1177/20406207211048959. eCollection 2021.
3
Phase II Trial of Pembrolizumab Plus Gemcitabine, Vinorelbine, and Liposomal Doxorubicin as Second-Line Therapy for Relapsed or Refractory Classical Hodgkin Lymphoma.
帕博利珠单抗联合吉西他滨、长春瑞滨和脂质体多柔比星作为二线治疗复发或难治性经典型霍奇金淋巴瘤的 II 期临床试验。
J Clin Oncol. 2021 Oct 1;39(28):3109-3117. doi: 10.1200/JCO.21.01056. Epub 2021 Jun 25.
4
Therapeutic Updates for Relapsed and Refractory Classical Hodgkin Lymphoma.复发难治性经典型霍奇金淋巴瘤的治疗进展
Cancers (Basel). 2020 Oct 8;12(10):2887. doi: 10.3390/cancers12102887.
5
PD-L1 and PD-L2 Genetic Alterations Define Classical Hodgkin Lymphoma and Predict Outcome.程序性死亡配体1(PD-L1)和程序性死亡配体2(PD-L2)基因改变可定义经典型霍奇金淋巴瘤并预测预后。
J Clin Oncol. 2016 Aug 10;34(23):2690-7. doi: 10.1200/JCO.2016.66.4482. Epub 2016 Apr 11.