Department of Rehabilitation Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Gannan Medical University, Ganzhou, China.
Eur J Clin Nutr. 2024 Jan;78(1):6-18. doi: 10.1038/s41430-023-01344-1. Epub 2023 Sep 22.
To investigate the effects of rapeseed oil on body composition, blood glucose and lipid metabolism in people with overweight and obesity compared to other cooking oils. We searched eight databases for randomized controlled studies (including randomized crossover trials). The risk of bias for the included studies was assessed using the Cochrane Risk of Bias 2.0 tool. The Grading of Recommendations Assessment Development and Evaluation (GRADE) criteria were used to evaluate the quality of the outcomes. The methodological quality of the included studies was assessed using the Physiotherapy Evidence Database (PEDro) scale. Sensitivity analysis was used to check the stability of the pooled results. Statistical analysis was carried out using Review Manager 5.3 software. As a result, fifteen randomized controlled studies (including six parallel studies and nine crossover studies) were included in this study. Compared to other edible oils, rapeseed oil significantly reduced low density lipoprotein cholesterol (LDL-C) (MD = -0.14 mmol/L, 95% CI: -0.21, -0.08, I = 0%, P < 0.0001), apolipoprotein B (ApoB) (MD = -0.03 g/L, 95% CI: -0.05, -0.01, I = 0%, P = 0.0003), ApoB/ApoA1 (MD = -0.02, 95% CI: -0.04, -0.00, I = 0%, P = 0.02) and insulin (MD = -12.45 pmol/L, 95% CI: -19.61, -5.29, I = 37%, P = 0.0007) levels, and increased fasting glucose (MD = 0.16 mmol/L, 95% CI: 0.05, 0.27, I = 27%, P = 0.003) levels. However, the differences in body weight and body composition between rapeseed oil and control oils were not significant. In a word, rapeseed oil is effective in reducing LDL-C, ApoB and ApoB/ApoA1 levels in people with overweight and obesity, which is helpful in preventing and reducing the risk of atherosclerosis. PROSPERO registration number: CRD42022333436.
为了研究菜籽油对超重和肥胖人群的身体成分、血糖和血脂代谢的影响，与其他食用油相比。我们在八个数据库中搜索了随机对照研究（包括随机交叉试验）。使用 Cochrane 偏倚风险 2.0 工具评估纳入研究的偏倚风险。使用推荐评估、制定和评价（GRADE）标准来评估结局的质量。使用物理治疗证据数据库（PEDro）量表评估纳入研究的方法学质量。使用敏感性分析检查汇总结果的稳定性。使用 Review Manager 5.3 软件进行统计分析。结果，本研究纳入了十五项随机对照研究（包括六项平行研究和九项交叉研究）。与其他食用油相比，菜籽油显著降低了低密度脂蛋白胆固醇（LDL-C）（MD=-0.14mmol/L，95%CI：-0.21，-0.08，I=0%，P<0.0001）、载脂蛋白 B（ApoB）（MD=-0.03g/L，95%CI：-0.05，-0.01，I=0%，P=0.0003）、ApoB/ApoA1（MD=-0.02，95%CI：-0.04，-0.00，I=0%，P=0.02）和胰岛素（MD=-12.45pmol/L，95%CI：-19.61，-5.29，I=37%，P=0.0007）水平，同时升高了空腹血糖（MD=0.16mmol/L，95%CI：0.05，0.27，I=27%，P=0.003）水平。然而，菜籽油与对照油在体重和身体成分方面的差异没有统计学意义。总之，菜籽油在降低超重和肥胖人群的 LDL-C、ApoB 和 ApoB/ApoA1 水平方面是有效的，有助于预防和降低动脉粥样硬化的风险。PROSPERO 注册号：CRD42022333436。
