Department of Obesity and Metabolic Disorders Treatment and Clinical Dietetics, Karol Marcinkowski University of Medical Sciences, ul. Szamarzewskiego 82/84, 60-569, Poznań, Polska, Poland.
Department of Gastroenterology, Dietetics and Internal Medicine, Karol Marcinkowski University of Medical Sciences, Poznan, Poland.
Lipids Health Dis. 2020 Jun 20;19(1):143. doi: 10.1186/s12944-020-01330-7.
Amaranth seed oil (ASO) and rapeseed oil (RSO) are functional foods that display antioxidant and hepatoprotective properties. These oils are also known to lower glucose and cholesterol levels. The current study compared the effects exerted by RSO and ASO on weight loss and metabolic parameters during a 3-week body mass reduction program.
Eighty-one obese subjects (BMI > 30 kg/m), aged 25-70 years, were enrolled in a 3-week body mass reduction program based on a calorie-restricted diet and physical activity. Participants were randomly categorized into an AO group (administered 20 mL/d of ASO), a RO group (administered 20 mL/d of RSO), and a C group (control; untreated). Anthropometric and metabolic parameters were measured at baseline and endpoint.
Significant decreases in weight, body mass index (BMI), waist circumference (WC), hip circumference (HC), fat mass (FM), lean body mass (LBM), visceral fat mass (VFM), and total body water (TBW%) were observed in all groups (P < 0.05). No significant improvements were observed in the clinical parameters of group C. Fasting insulin (Δ - 5.9, and Δ - 5.7) and homeostatic model assessment of insulin resistance (HOMA-IR) (Δ - 1.1 and Δ - 0.5) were decreased in both RO and AO groups, respectively. Fasting glucose (Δ -8.5; P = 0.034), total cholesterol (Δ -14.6; P = 0.032), non-HDL cholesterol (Δ 15.9; P = 0.010), TG/HDL ratio (Δ -0.6; P = 0.032), LDL cholesterol (Δ -12.3; P = 0.042), and triglycerides (Δ -6.5; P = 0.000) were significantly improved in the AO group, compared to the RO group.
The 3-week body mass reduction intervention caused a significant reduction in the weight, BMI, WC, HC, FM, and VFM of all groups. Except for HOMA-IR, there were no statistical differences between the clinical parameters of all groups. However, a trend toward improved insulin levels and HDL% was noticeable in AO and RO. Therapies involving edible oils with high nutritional value, such as RSO and ASO, show potential for improving metabolic measurements during body mass reduction programs. Thus, obese patients undertaking weight reduction programs may benefit from RSO and ASO supplementation.
retrospectively registered, DRKS00017708.
苋菜籽和油菜籽油都是具有抗氧化和保肝作用的功能性食品。这两种油还可以降低血糖和胆固醇水平。本研究比较了油菜籽油和苋菜籽在为期 3 周的体重减轻计划中对减肥和代谢参数的影响。
81 名肥胖受试者（BMI＞30kg/m），年龄 25-70 岁，参加了一项基于热量限制饮食和体力活动的为期 3 周的体重减轻计划。参与者被随机分为 AO 组（每天给予 20ml 苋菜籽）、RO 组（每天给予 20ml 油菜籽油）和 C 组（对照组；未治疗）。在基线和终点测量体重、体重指数（BMI）、腰围（WC）、臀围（HC）、体脂（FM）、瘦体重（LBM）、内脏脂肪量（VFM）和总体液量（TBW%）。
所有组的体重、BMI、WC、HC、FM、LBM、VFM 和 TBW%均显著降低（P＜0.05）。C 组的临床参数无显著改善。RO 和 AO 组的空腹胰岛素（Δ-5.9，和 Δ-5.7）和稳态模型评估的胰岛素抵抗（HOMA-IR）（Δ-1.1 和 Δ-0.5）分别降低。AO 组的空腹血糖（Δ-8.5；P=0.034）、总胆固醇（Δ-14.6；P=0.032）、非高密度脂蛋白胆固醇（Δ 15.9；P=0.010）、TG/HDL 比值（Δ-0.6；P=0.032）、LDL 胆固醇（Δ-12.3；P=0.042）和甘油三酯（Δ-6.5；P=0.000）显著改善，与 RO 组相比。
3 周的体重减轻干预导致所有组的体重、BMI、WC、HC、FM 和 VFM 显著降低。除 HOMA-IR 外，各组临床参数无统计学差异。然而，AO 和 RO 组的胰岛素水平和 HDL%有改善趋势。富含营养的食用油（如油菜籽油和苋菜籽）治疗可能有助于改善体重减轻计划中的代谢指标。因此，进行体重减轻计划的肥胖患者可能受益于油菜籽油和苋菜籽的补充。
回顾性注册，DRKS00017708。
