Jiang Xiaoying
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, 76 Yanta West Road, Xi'an, 710061, Shaanxi, China.
Clin Exp Med. 2023 Nov;23(7):3339-3347. doi: 10.1007/s10238-023-01191-1. Epub 2023 Sep 22.
Fibrosis is the excess deposition of extracellular matrix involved in the pathogenesis of chronic diseases and finally leads to the disruption of tissue architecture and failure of organ function. Long noncoding RNAs (lncRNAs) are a class of RNAs with lengths greater than 200 nucleotides and do not code proteins, which regulate gene expression at multiple levels. Nuclear-enriched abundant transcript 1 (NEAT1) is a long noncoding RNA that is widely expressed in mammalian cells and known as essential architectural scaffold for the formation of paraspeckles. Recently, the accumulating studies demonstrated that lncRNA NEAT1 was remarkable upregulated in the development of fibrosis in different organs, such as liver fibrosis, renal fibrosis, cardiac fibrosis, and lung fibrosis. More importantly, knockdown of NEAT1 remarkably alleviated fibrosis in vitro and in vivo. In this review, we summarized current studies of NEAT1 in fibrosis and hopefully aid in a better understanding of the mechanisms of fibrosis and the potential of NEAT1 as novel therapeutic target for fibrosis.
纤维化是细胞外基质过度沉积，参与慢性疾病的发病机制，最终导致组织结构破坏和器官功能衰竭。长链非编码RNA（lncRNAs）是一类长度大于200个核苷酸且不编码蛋白质的RNA，可在多个水平上调节基因表达。核富集丰富转录本1（NEAT1）是一种长链非编码RNA，在哺乳动物细胞中广泛表达，是形成旁斑的重要结构支架。最近，越来越多的研究表明，lncRNA NEAT1在不同器官的纤维化发展过程中显著上调，如肝纤维化、肾纤维化、心脏纤维化和肺纤维化。更重要的是，敲低NEAT1在体外和体内均能显著减轻纤维化。在这篇综述中，我们总结了目前关于NEAT1在纤维化方面的研究，希望有助于更好地理解纤维化的机制以及NEAT1作为纤维化新治疗靶点的潜力。
