Masson Rahul, Jeong Charlotte Y, Ma Elaine, Crew Ashley B, Fragoso Natalie M, Shi Vivian Y, Hsiao Jennifer L
Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Dermatol Ther (Heidelb). 2023 Nov;13(11):2487-2526. doi: 10.1007/s13555-023-01018-7. Epub 2023 Sep 22.
Dissecting cellulitis of the scalp (DCS) is a chronic inflammatory skin condition characterized by abscesses, nodules, fistulas, and scarring alopecia. Management of this oftentimes debilitating dermatosis can be challenging due to its recalcitrant nature. There is limited data regarding the efficacy of treatment options for DCS.
The aim of this study was to conduct a systematic review of the literature to explore the efficacy and safety of reported DCS treatments.
In October 2022, MEDLINE and EMBASE databases were searched for articles on treatments for DCS. Studies that contained outcome efficacy data for DCS treatments were included. Reviews, conference abstracts, meta-analyses, commentaries, non-relevant articles, and articles with no full-text available were excluded. Data extraction was performed by two independent reviewers.
A total of 110 relevant articles with 417 patients were identified. A majority of studies (86.4%) were case reports or series. Treatment options included systemic antibiotics, oral retinoids, biologics, procedural treatments, combination agents, and topical treatments. Oral retinoids and photodynamic therapy were the most extensively studied medical and procedural interventions, respectively.
Overall, randomized controlled trials are needed to evaluate various treatment regimens for DCS and provide patients with a robust, evidence-based approach to therapy.
头皮穿掘性蜂窝织炎（DCS）是一种慢性炎症性皮肤病，其特征为脓肿、结节、瘘管和瘢痕性脱发。由于这种皮肤病顽固难治，对其进行治疗往往具有挑战性。关于DCS治疗方案疗效的数据有限。
本研究的目的是对文献进行系统综述，以探讨已报道的DCS治疗方法的疗效和安全性。
2022年10月，检索MEDLINE和EMBASE数据库中有关DCS治疗的文章。纳入包含DCS治疗结果疗效数据的研究。排除综述、会议摘要、荟萃分析、评论、不相关文章以及无全文的文章。由两名独立 reviewers 进行数据提取。
共识别出110篇相关文章，涉及417例患者。大多数研究（86.4%）为病例报告或病例系列。治疗方案包括全身用抗生素、口服维甲酸、生物制剂、程序性治疗、联合用药和局部治疗。口服维甲酸和光动力疗法分别是研究最广泛的药物和程序性干预措施。
总体而言，需要进行随机对照试验来评估DCS的各种治疗方案，并为患者提供一种可靠的、基于证据的治疗方法。
