Renaissance School of Medicine at Stony Brook University, 1320 Stony Brook Rd., Building F, Suite 200, Stony Brook, NY, 11790, USA.
Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA.
Drugs R D. 2021 Mar;21(1):29-37. doi: 10.1007/s40268-020-00335-y. Epub 2021 Jan 2.
Dissecting cellulitis of the scalp is a primary scarring alopecia. Isotretinoin is commonly referenced in the literature as a treatment for dissecting cellulitis. The objective of this article was to conduct a review and meta-analysis to assess the efficacy of isotretinoin for treating dissecting cellulitis of the scalp.
The following databases were searched for articles prior to 23 June, 2019: PubMed, Embase, Cochrane Central, CINAHL, and Web of Science. Multi-patient studies (more than three) that reported on the administration of isotretinoin for dissecting cellulitis were included. A pooled meta-analysis for improvement of disease burden after isotretinoin administration in patients with dissecting cellulitis of the scalp was performed. A fixed-effects model was used.
Five articles were ultimately used for the quantitative meta-analysis. The overall efficacy rate of isotretinoin in treating dissecting cellulitis of the scalp was estimated to be 0.9 with a 95% confidence interval (0.81-0.97). The sensitivity analysis suggested that the overall efficacy is still very high, with a range of 0.83-0.94. Recurrence was seen in 24% (6/25) of patients. Common associated diseases amongst patients with dissecting cellulitis of the scalp were acne conglobata 20% (30/151) and hidradenitis suppurativa 19% (11/72).
Isotretinoin is an effective treatment for improving symptoms of dissecting cellulitis of the scalp. Disease recurrence is a common finding for those who undergo successful treatment.
头皮解剖性蜂窝织炎是一种原发性瘢痕性脱发。异维 A 酸在文献中常被提及为治疗头皮解剖性蜂窝织炎的方法。本文旨在进行综述和荟萃分析，以评估异维 A 酸治疗头皮解剖性蜂窝织炎的疗效。
在 2019 年 6 月 23 日之前，检索了以下数据库中的文章：PubMed、Embase、Cochrane 中央、CINAHL 和 Web of Science。纳入了报告多例（超过 3 例）患者接受异维 A 酸治疗头皮解剖性蜂窝织炎的多患者研究。对接受异维 A 酸治疗的头皮解剖性蜂窝织炎患者的疾病负担改善进行了汇总荟萃分析。使用固定效应模型。
最终有 5 篇文章用于定量荟萃分析。异维 A 酸治疗头皮解剖性蜂窝织炎的总体有效率估计为 0.9，95%置信区间（0.81-0.97）。敏感性分析表明，总体疗效仍然非常高，范围为 0.83-0.94。24%（6/25）的患者出现复发。头皮解剖性蜂窝织炎患者常见的相关疾病包括聚合性痤疮 20%（30/151）和化脓性汗腺炎 19%（11/72）。
异维 A 酸是改善头皮解剖性蜂窝织炎症状的有效治疗方法。成功治疗后，疾病复发是常见现象。
