Department of Mental Health, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 1130033, Japan.
BMC Res Notes. 2023 Sep 22;16(1):230. doi: 10.1186/s13104-023-06512-x.
This study aimed to examine whether a high score on the euthymia scale (ES) predicts a low incidence of depressive symptoms one year later.
The baseline online survey was conducted in February 2020, and a follow-up survey was done in February 2021. Japanese over 20 years old were enrolled. Respondents who answered both baseline and follow-up, and without depressive symptoms at baseline were included in the analysis. The euthymia scores at baseline was measured by the 10 items of the Japanese version of the ES. Depressive symptoms at follow-up were determined if participants showed either depressive feelings or anhedonia. The odds ratio (OR) was calculated using multivariate logistic regression analysis, adjusting for age, gender, marital status, educational attainment, and clinical visit for depressive episode before the baseline survey.
The total of 624 participants were analyzed. A total of n = 63 (10.1%) presented depressive symptom at follow-up. A high ES score significantly predicted a lower incidence of depressive symptoms, after adjusting for covariates (aOR = 0.81 [95% confidence interval: 0.72-0.89]). Using the cutoff score retrieved from this data, a high ES score (7 or more) showed the same tendency, compared to a low ES score (< 7) (aOR = 0.46 [0.25-0.83]).
This study suggests the predictive usefulness of euthymia for subsequent depressive symptoms. Further investigation is needed by employing rigid diagnostic criteria.
本研究旨在探讨心境正常量表（ES）高分是否能预测一年后抑郁症状的低发生率。
基线在线调查于 2020 年 2 月进行，随访调查于 2021 年 2 月进行。招募年龄在 20 岁以上的日本人。纳入同时完成基线和随访调查、且基线时无抑郁症状的应答者。基线时的心境正常评分采用日本版 ES 的 10 项进行测量。如果参与者表现出抑郁感或快感缺失，则在随访时确定抑郁症状。采用多变量逻辑回归分析，调整年龄、性别、婚姻状况、教育程度和基线调查前因抑郁发作而就诊的情况，计算比值比（OR）。
共分析了 624 名参与者。共有 n=63（10.1%）在随访时出现抑郁症状。调整了协变量后，高 ES 评分显著预测了抑郁症状的低发生率（aOR=0.81[95%置信区间：0.72-0.89]）。使用从该数据中获得的截断分数，与低 ES 评分（<7）相比，高 ES 评分（7 或更高）显示出相同的趋势（aOR=0.46[0.25-0.83]）。
本研究表明，心境正常对随后的抑郁症状具有预测作用。需要采用严格的诊断标准进行进一步的研究。
