Sequential organo and metal catalyzed reaction between 3-pyrrolyloxindoles and linear nitroenynes: access to cyclic aza-spirooxindoles.
作者信息
Biswas Subhankar, Purkayastha Siddhartha K, Guha Ankur K, Pan Subhas Chandra
机构信息
Department of Chemistry, Indian Institute of Technology Guwahati, 781039, India.
Department of Chemistry, Cotton University, Assam, 781001, India.
出版信息
Chem Commun (Camb). 2023 Oct 10;59(81):12156-12159. doi: 10.1039/d3cc03713d.
PMID:37740344
Abstract
An asymmetric Michael addition/hydroarylation reaction sequence, catalyzed by a sequential catalytic system consisting of a squaramide and a combination of silver and gold salts, provides a new series of cyclic aza-spirooxindole derivatives in excellent yields (up to 94%) and high diastero- and enantioselectivities (up to 7 : 1 dr, up to >99% ee). Computational study has also been performed.
摘要
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