Harisinghani Ayesha, Dhand Amar, Steffensen Ellen Hollands, Skotko Brian G
Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA.
Department of Neurology, Division of Hospital Medicine, Division of Stroke and Cerebrovascular Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Am J Med Genet C Semin Med Genet. 2024 Mar;196(1):e32064. doi: 10.1002/ajmg.c.32064. Epub 2023 Sep 22.
Research continues to demonstrate that the characteristics of one's social network could have an impact on the development of Alzheimer's disease. Given the predisposition of people with Down syndrome to develop Alzheimer's disease, analysis of their social networks has become an emerging focus. Previous pilot research demonstrated that the personal networks of people with DS could be quantitatively analyzed, with no difference between self-report and parent-proxy report. This manuscript focuses on a 12-month follow-up period with the same original participants (24 adults with Down syndrome). Their social networks demonstrated sustainability, but not improvement, as reported by people with DS (mean network size: 8.88; mean density: 0.73; mean constraint: 0.44; mean effective size: 3.58; mean max degree: 6.04; mean degree: 4.78) and their proxies (mean network size: 7.90; mean density: 0.82; mean constraint: 53.13; mean effective size: 2.87; mean max degree: 5.19; mean degree: 4.30). Intentional and continued efforts are likely needed in order to improve the social network measures of people with Down syndrome.
研究不断表明，一个人的社交网络特征可能会对阿尔茨海默病的发展产生影响。鉴于唐氏综合征患者易患阿尔茨海默病，对他们社交网络的分析已成为一个新的焦点。先前的初步研究表明，唐氏综合征患者的个人网络可以进行定量分析，自我报告和家长代理报告之间没有差异。本手稿聚焦于对相同的原始参与者（24名成年唐氏综合征患者）进行为期12个月的随访。正如唐氏综合征患者（平均网络规模：8.88；平均密度：0.73；平均约束性：0.44；平均有效规模：3.58；平均最大度数：6.04；平均度数：4.78）及其代理人（平均网络规模：7.90；平均密度：0.82；平均约束性：53.13；平均有效规模：2.87；平均最大度数：5.19；平均度数：4.30）所报告的那样，他们的社交网络显示出可持续性，但没有改善。为了改善唐氏综合征患者的社交网络指标，可能需要有意且持续的努力。
