Rahangdale Rakesh, Tender Tenzin, Balireddy Sridevi, Goswami Kamini, Pasupuleti Mukesh, Hariharapura Raghu Chandrashekar
Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Microbiology Division, Council of Scientific and Industrial Research, Central Drug Research Institute, Lucknow, Uttar Pradesh, India.
Microb Biotechnol. 2023 Nov;16(11):2036-2052. doi: 10.1111/1751-7915.14342. Epub 2023 Sep 23.
The health of the human population has been continuously challenged by viral infections. Herpes simplex virus (HSV) is one of the common causes of illness and can lead to death in immunocompromised patients. Existing anti-HSV therapies are not completely successful in eliminating the infection due to anti-viral drug resistance, ineffectiveness against the latent virus and high toxicity over prolonged use. There is a need to update our knowledge of the current challenges faced in anti-HSV therapeutics and realize the necessity of developing alternative treatment approaches. Protein therapeutics are now being explored as a novel approach due to their high specificity and low toxicity. This review highlights the significance of HSV viral glycoproteins and host receptors in the pathogenesis of HSV infection. Proteins or peptides derived from HSV glycoproteins gC, gB, gD, gH and host cell receptors (HSPG, nectin and HVEM) that act as decoys to inhibit HSV attachment, entry, or fusion have been discussed. Few researchers have tried to improve the efficacy and stability of the identified peptides by modifying them using a peptidomimetic approach. With these efforts, we think developing an alternative treatment option for immunocompromised patients and drug-resistant organisms is not far off.
人类健康一直受到病毒感染的持续挑战。单纯疱疹病毒（HSV）是常见的致病原因之一，可导致免疫功能低下患者死亡。由于抗病毒药物耐药性、对潜伏病毒无效以及长期使用毒性高，现有的抗HSV疗法在消除感染方面并不完全成功。有必要更新我们对抗HSV治疗当前面临挑战的认识，并认识到开发替代治疗方法的必要性。由于蛋白质疗法具有高特异性和低毒性，目前正在探索将其作为一种新方法。本综述强调了HSV病毒糖蛋白和宿主受体在HSV感染发病机制中的重要性。讨论了源自HSV糖蛋白gC、gB、gD、gH和宿主细胞受体（硫酸乙酰肝素蛋白聚糖、nectin和疱疹病毒侵入介导因子）的蛋白质或肽，它们作为诱饵抑制HSV的附着、进入或融合。很少有研究人员尝试通过拟肽方法修饰已鉴定的肽来提高其疗效和稳定性。通过这些努力，我们认为为免疫功能低下患者和耐药生物体开发替代治疗方案并不遥远。
