Costall B, Domeney A M, Naylor R J, Tattersall F D
Neuropharmacology. 1986 Aug;25(8):959-61. doi: 10.1016/0028-3908(86)90030-4.
The administration to the ferret of cisplatin, 10mg/kg (i.v.), caused an intense emetic response that was prevented by ICS 205-930 (0.1 and 1.0 mg/kg i.v.) and metoclopramide (4.0 mg/kg i.v.). Smaller doses of ICS 205-930 (0.01 mg/kg i.v.) and metoclopramide (2.0 mg/kg i.v.) attenuated the emetic response to cisplatin. It is concluded that the potent action of ICS 205-930 against cisplatin-induced emesis is the consequence of a 5-hydroxytryptamine M-receptor antagonism which may also contribute to the antiemetic action of metoclopramide.
给雪貂静脉注射10mg/kg顺铂会引发强烈的呕吐反应，而ICS 205 - 930（静脉注射0.1和1.0mg/kg）和甲氧氯普胺（静脉注射4.0mg/kg）可预防该反应。较小剂量的ICS 205 - 930（静脉注射0.01mg/kg）和甲氧氯普胺（静脉注射2.0mg/kg）可减弱对顺铂的呕吐反应。得出的结论是，ICS 205 - 930对顺铂诱导呕吐的强效作用是5 - 羟色胺M受体拮抗作用的结果，这也可能有助于甲氧氯普胺的止吐作用。
