Terry Natalie, Margolis Kara Gross
Division of Pediatric Gastroenterology, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Division of Pediatric Gastroenterology, Department of Pediatrics, Morgan Stanley Children's Hospital, Columbia University Medical Center, New York, NY, USA.
Handb Exp Pharmacol. 2017;239:319-342. doi: 10.1007/164_2016_103.
Serotonin (5-hydroxytryptamine; 5-HT) is best known as a neurotransmitter critical for central nervous system (CNS) development and function. 95% of the body's serotonin, however, is produced in the intestine where it has been increasingly recognized for its hormonal, autocrine, paracrine, and endocrine actions. This chapter provides the most current knowledge of the critical autocrine and paracrine roles of 5-HT in intestinal motility and inflammation as well as its function as a hormone in osteocyte homeostasis. Therapeutic applications in each of these areas are also discussed.
血清素（5-羟色胺；5-HT）作为一种对中枢神经系统（CNS）发育和功能至关重要的神经递质而广为人知。然而，人体95%的血清素是在肠道中产生的，其在肠道中的激素、自分泌、旁分泌和内分泌作用日益受到认可。本章提供了关于5-HT在肠道运动和炎症中关键的自分泌和旁分泌作用及其作为骨细胞内稳态激素功能的最新知识。还讨论了在这些领域中的治疗应用。
