Key Laboratory of Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, PR China; State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, PR China.
Key Laboratory of Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, PR China; State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, PR China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, PR China.
Sci Total Environ. 2023 Dec 15;904:167204. doi: 10.1016/j.scitotenv.2023.167204. Epub 2023 Sep 21.
Disinfectants and their mixtures can induce hormesis. However, how the mixture hormesis is related to those of components and the interactions in disinfectant mixtures remain unclear. In this paper, the luminescence inhibition toxicities of chlorinated sodium phosphate (CSP), dodecyl dimethyl benzyl ammonium bromide (DOB), dodecyl dimethyl benzyl ammonium chloride (DOC), ethanol (EtOH), glutaraldehyde (GLA), hydrogen peroxide (HO), isopropyl alcohol (IPA), n-propanol (NPA), and 20 mixture rays in four mixture systems (EtOH-HO, DOB-HO, DOC-EtOH, and EtOH-IPA-NPA) containing at least one component showing hormesis to Vibrio qinghaiensis sp.-Q67 (Q67) were determined at 0.25, 3, 6, 9, and 12 h. The synergism-antagonism heatmap based on independent action model (noted as SAHmap) was developed to systematically evaluate the interactions in various mixtures. It was shown that five disinfectants (CSP, EtOH, HO, NPA, and IPA) and 17 mixture rays exhibited time-dependent hormesis. The hormetic component was responsible for the hormesis of the mixture rays. Most mixture rays showed low- concentration/dose additive action and high-concentration/dose synergism at different time. This study further exemplified the interrelationship between the hormesis in the mixtures and their components and implied the need to pay attention to the time-dependent hormesis and interactions induced by the disinfectants.
消毒剂及其混合物可诱导兴奋效应。然而，消毒剂混合物的兴奋效应与成分的兴奋效应以及消毒剂混合物中的相互作用之间的关系尚不清楚。在本文中，测定了至少含有一种表现出对青海弧菌 Q67 兴奋效应的成分的四种混合物体系（EtOH-HO、DOB-HO、DOC-EtOH 和 EtOH-IPA-NPA）中 20 种混合物射线在 0.25、3、6、9 和 12 h 时对发光抑制毒性氯代磷酸二钠（CSP）、十二烷基二甲基苄基氯化铵（DOB）、十二烷基二甲基苄基氯化铵（DOC）、乙醇（EtOH）、戊二醛（GLA）、过氧化氢（HO）、异丙醇（IPA）、正丙醇（NPA）和 Vibrio qinghaiensis sp.-Q67（Q67）的抑制毒性。基于独立作用模型（记为 SAHmap）开发了协同-拮抗热图，以系统评估各种混合物中的相互作用。结果表明，五种消毒剂（CSP、EtOH、HO、NPA 和 IPA）和 17 种混合物射线表现出时间依赖性兴奋效应。兴奋效应成分是混合物射线兴奋效应的原因。大多数混合物射线在不同时间表现出低浓度/剂量相加作用和高浓度/剂量协同作用。本研究进一步说明了混合物中的兴奋效应与其成分之间的相互关系，并暗示需要注意消毒剂引起的时间依赖性兴奋效应和相互作用。
