Zeng Guang-Gui, Zhou Jing, Jiang Wan-Li, Yu Jiang, Nie Gui-Ying, Li Jing, Zhang Shi-Qian, Tang Chao-Ke
Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China; 2020 Grade Excellent Doctor Class of Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China.
Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China; School of Pharmaceutical Science, University of South China, Hengyang City, Hunan Province 421001, PR China.
Curr Probl Cardiol. 2024 Jan;49(1 Pt B):102096. doi: 10.1016/j.cpcardiol.2023.102096. Epub 2023 Sep 21.
Nuclear factor interleukin-3 (NFIL3), a proline- and acidic-residue-rich (PAR) bZIP transcription factor, is called the E4 binding protein 4 (E4BP4) as well, which is relevant to regulate the circadian rhythms and the viability of cells. More and more evidence has shown that NFIL3 is associated with different cardiovascular diseases. In recent years, it has been found that NFIL3 has significant functions in the progression of atherosclerosis (AS) via the regulation of inflammatory response, macrophage polarization, some immune cells and lipid metabolism. In this overview, we sum up the function of NFIL3 during the development of AS and offer meaningful views how to treat cardiovascular disease related to AS.
核因子白细胞介素-3（NFIL3）是一种富含脯氨酸和酸性残基（PAR）的bZIP转录因子，也被称为E4结合蛋白4（E4BP4），它与调节昼夜节律和细胞活力有关。越来越多的证据表明，NFIL3与不同的心血管疾病有关。近年来，人们发现NFIL3通过调节炎症反应、巨噬细胞极化、一些免疫细胞和脂质代谢，在动脉粥样硬化（AS）的进展中具有重要作用。在本综述中，我们总结了NFIL3在AS发展过程中的作用，并就如何治疗与AS相关的心血管疾病提出了有意义的观点。
