Keniry Megan, Dearth Robert K, Persans Michael, Parsons Ramon
Department of Biology, University of Texas- Pan American, 1201 W. University Dr., Edinburg, TX 78539, USA.
Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave HCSM 6-117, New York, NY 10029, USA.
Discoveries (Craiova). 2014 Apr-Jun;2(2):e15. doi: 10.15190/d.2014.7.
The bZIP transcription factor NFIL3 (Nuclear factor Interleukin 3 regulated, also known as E4 binding protein 4, E4BP4) regulates diverse biological processes from circadian rhythm to cellular viability. Recently, a host of novel roles have been identified for NFIL3 in immunological signal transduction, cancer, aging and metabolism. Elucidating the signaling pathways that are impacted by NFIL3 and the regulatory mechanisms that it targets, inhibits or activates will be critical for developing a clearer picture of its physiological roles in disease and normal processes. This review will discuss the recent advances and emerging issues regarding NFIL3-mediated transcriptional regulation of CEBPβ and FOXO1 activated genes and signal transduction.
碱性亮氨酸拉链转录因子NFIL3（核因子白细胞介素3调节因子，也称为E4结合蛋白4，E4BP4）调节从昼夜节律到细胞活力等多种生物学过程。最近，已确定NFIL3在免疫信号转导、癌症、衰老和代谢中具有许多新作用。阐明受NFIL3影响的信号通路以及它所靶向、抑制或激活的调节机制，对于更清楚地了解其在疾病和正常过程中的生理作用至关重要。本综述将讨论关于NFIL3介导的CEBPβ和FOXO1激活基因的转录调控以及信号转导的最新进展和新出现的问题。
