葡萄糖-6-磷酸脱氢酶缺乏加速糖尿病患者的动脉老化。
Glucose-6-phosphate dehydrogenase deficiency accelerates arterial aging in diabetes.
机构信息
Dipartimento Scienze Mediche e Sanita' Pubblica, Universita' di Cagliari, Cagliari, Italy.
Internal Medicine Unit, Policlinico Universitario Monserrato, AOU Cagliari, Cagliari, Italy.
出版信息
Acta Diabetol. 2024 Jan;61(1):127-130. doi: 10.1007/s00592-023-02118-8. Epub 2023 Sep 23.
AIMS
High glucose levels and Glucose-6-Phosphate Dehydrogenase deficiency (G6PDd) have both tissue inflammatory effects. Here we determined whether G6PDd accelerates arterial aging (information linked stiffening) in diabetes.
METHODS
Plasma glucose, interleukin 6 (IL6), and arterial stiffness (indexed as carotid-femoral Pulse Wave Velocity, PWV) and red blood cell G6PD activity were assessed in a large (4448) Sardinian population.
RESULTS
Although high plasma glucose in diabetics, did not differ by G6DP status (178.2 ± 55.1 vs 169.0 ± 50.1 mg/dl) in G6DPd versus non-G6PDd subjects, respectively, IL6, and PWV (adjusted for age and glucose) were significantly increased in G6PDd vs non-G6PDd subjects (PWV, 8.0 ± 0.4 vs 7.2 ± 0.2 m/sec) and (IL6, 6.9 ± 5.0 vs 4.2 ± 3.0 pg/ml). In non-diabetics, neither fasting plasma glucose, nor IL6, nor PWV were impacted by G6PDd.
CONCLUSION
G6PDd in diabetics is associated with increased inflammatory markers and accelerated arterial aging.
目的
高血糖水平和葡萄糖-6-磷酸脱氢酶缺乏症（G6PDd）均具有组织炎症作用。在这里，我们确定了 G6PDd 是否会加速糖尿病患者的动脉老化（与僵硬相关的信息）。
方法
在一个大型（4448 人）撒丁岛人群中评估了血浆葡萄糖、白细胞介素 6（IL6）和动脉僵硬（以颈动脉-股动脉脉搏波速度，PWV 为指标）以及红细胞 G6PD 活性。
结果
尽管糖尿病患者的高血糖水平在 G6DP 状态（G6PDd 组为 178.2 ± 55.1mg/dl，非 G6PDd 组为 169.0 ± 50.1mg/dl）上没有差异，但 G6PDd 组的 IL6 和 PWV（按年龄和血糖调整）明显高于非 G6PDd 组（PWV 为 8.0 ± 0.4m/sec 比 7.2 ± 0.2m/sec；IL6 为 6.9 ± 5.0pg/ml 比 4.2 ± 3.0pg/ml）。在非糖尿病患者中，空腹血糖、IL6 或 PWV 均不受 G6PDd 的影响。
结论
糖尿病患者的 G6PDd 与炎症标志物增加和动脉老化加速有关。
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