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To help aging populations, classify organismal senescence.

作者信息

Calimport Stuart R G, Bentley Barry L, Stewart Claire E, Pawelec Graham, Scuteri Angelo, Vinciguerra Manlio, Slack Cathy, Chen Danica, Harries Lorna W, Marchant Gary, Fleming G Alexander, Conboy Michael, Antebi Adam, Small Gary W, Gil Jesus, Lakatta Edward G, Richardson Arlan, Rosen Clifford, Nikolich Karoly, Wyss-Coray Tony, Steinman Lawrence, Montine Thomas, de Magalhães João Pedro, Campisi Judith, Church George

机构信息

The list of author affiliations is available in the supplementary materials.

出版信息

Science. 2019 Nov 1;366(6465):576-578. doi: 10.1126/science.aay7319.

DOI:10.1126/science.aay7319
PMID:31672885
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7193988/
Abstract
摘要

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本文引用的文献

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Aging Classified as a Cause of Disease in ICD-11.衰老在《国际疾病分类第11版》中被列为一种疾病原因。
Rejuvenation Res. 2019 Aug;22(4):281. doi: 10.1089/rej.2019.2242.
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Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study.特发性肺纤维化中的衰老细胞清除:首次人体、开放标签、先导研究的结果。
EBioMedicine. 2019 Feb;40:554-563. doi: 10.1016/j.ebiom.2018.12.052. Epub 2019 Jan 5.
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Plasma proteomic signature of age in healthy humans.健康人体中与年龄相关的血浆蛋白质组特征。
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Hallmarks of Cellular Senescence.细胞衰老的特征。
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Reversing the Life Cycle: Medusae Transforming into Polyps and Cell Transdifferentiation in Turritopsis nutricula (Cnidaria, Hydrozoa).逆转生命周期:灯塔水母(刺胞动物门,水螅纲)中的水母型转化为水螅型及细胞转分化
Biol Bull. 1996 Jun;190(3):302-312. doi: 10.2307/1543022.
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Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin.游离DNA包含一种体内核小体足迹,可告知其组织来源。
Cell. 2016 Jan 14;164(1-2):57-68. doi: 10.1016/j.cell.2015.11.050.
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Editorial.社论。
Mech Ageing Dev. 2015 Nov;151:1. doi: 10.1016/j.mad.2015.08.008. Epub 2015 Sep 14.
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Cellular senescence: from physiology to pathology.细胞衰老:从生理学到病理学。
Nat Rev Mol Cell Biol. 2014 Jul;15(7):482-96. doi: 10.1038/nrm3823.
9
The hallmarks of aging.衰老的特征。
Cell. 2013 Jun 6;153(6):1194-217. doi: 10.1016/j.cell.2013.05.039.
10
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.衰老相关分泌表型揭示了致癌RAS和p53肿瘤抑制因子的细胞非自主功能。
PLoS Biol. 2008 Dec 2;6(12):2853-68. doi: 10.1371/journal.pbio.0060301.