Cook A J, Woolf C J, Wall P D
Neurosci Lett. 1986 Sep 25;70(1):91-6. doi: 10.1016/0304-3940(86)90443-x.
A standard suprathreshold mechanical stimulus applied to the hindpaw of decerebrate-spinal rats produces a discharge in hamstring flexor alpha-motoneurones which is stable for hours, provided no tissue injury is produced. Tissue injury results, however, in a decrease of threshold and an increase in the responsiveness of the reflex. This reflex hypersensitivity can be mimicked by brief (20 s) low frequency (1 Hz) conditioning stimuli to muscle or cutaneous nerves, if C-fibres are recruited. The prolonged post-conditioning facilitation of the flexion reflex by C-afferent volleys is now shown to be independent of changes in the excitability of the test afferent terminals in the dorsal horn and of the motoneurones. The hypersensitivity is therefore due to changes in the interneurones that link cutaneous nociceptive afferents with flexor motoneurones.
对去大脑脊髓大鼠的后爪施加标准的阈上机械刺激，会在绳肌屈肌α运动神经元中产生放电，只要不造成组织损伤，这种放电会持续数小时保持稳定。然而，组织损伤会导致阈值降低和反射反应性增加。如果募集了C纤维，通过对肌肉或皮神经进行短暂（20秒）低频（1赫兹）的条件刺激，可以模拟这种反射超敏反应。现已表明，C类传入神经冲动对屈曲反射的长时间条件后易化与背角中测试传入神经末梢和运动神经元的兴奋性变化无关。因此，超敏反应是由于将皮肤伤害性传入神经与屈肌运动神经元联系起来的中间神经元发生了变化。
