Bourque C W
Neurosci Lett. 1986 Oct 8;70(2):204-9. doi: 10.1016/0304-3940(86)90464-7.
Magnocellular neurosecretory cells (MNCs) were impaled in perfused explants of rat hypothalamus. Application of a voltage clamp after 1-5 current-evoked spikes revealed a tetrodotoxin-resistant, but Cd2+-sensitive inward current. From a threshold near -85 mV, the amplitude of this current increased as post-spike commands were made to more positive potentials. Following its activation, the current-voltage relation of the cell displayed a region of negative resistance which crossed the spike threshold. This Ca2+-dependent spike after-current can therefore induce and sustain burst firing in MNCs.
在大鼠下丘脑灌流外植体中对大细胞神经分泌细胞（MNCs）进行刺入。在1 - 5个电流诱发的动作电位后施加电压钳，揭示了一种对河豚毒素有抗性但对Cd2 +敏感的内向电流。从接近 - 85 mV的阈值开始，随着动作电位后指令电位变得更正，该电流的幅度增加。激活后，细胞的电流 - 电压关系显示出一个负电阻区域，该区域跨越动作电位阈值。因此，这种依赖Ca2 +的动作电位后电流可以诱导并维持MNCs的爆发式放电。
