Choi Jae-Ho, Lee Ju-Hyeong, Jo A-Hyun, Choi Young Jae, Choi Cheol Young, Kang Ju-Chan, Kim Jun-Hwan
Department of Aquatic Life Medicine, Pukyong National University, Busan 608-737, the Republic of Korea.
Department of Aquatic Life and Medical Science, Sun Moon University, Asan-si, the Republic of Korea.
Ecotoxicol Environ Saf. 2023 Oct 15;265:115469. doi: 10.1016/j.ecoenv.2023.115469. Epub 2023 Sep 22.
This study aimed to determine the toxicity standard and potential risks and effects of polyamide (PA) exposure on neurotoxicity, stress indicators, and immune responses in juvenile crucian carp Carassius carassius. Numerous microplastics (MPs) exists within aquatic environments, leading to diverse detrimental impacts on aquatic organisms. The C. carassius (mean weight, 23.7 ± 1.6 g; mean length, 13.9 ± 1.4 cm) were exposed to PA concentrations of 0, 4, 8, 16, 32 and 64 mg/L for 2 weeks. Among the neurotransmitters, the acetylcholinesterase (AChE) activity in the liver, gill, and intestine of C. carassius was significantly inhibited by PA exposure. Stress indicators such as cortisol and heat shock protein 70 (HSP70) in the liver, gill, and intestine of C. carassius were significantly increased, while immune responses to lysozyme and immunoglobulin M (IgM) were significantly decreased. Our study demonstrates the toxic effects of MP exposure on crucian carp's neurotoxicity, stress indicators, and immune responses.
本研究旨在确定聚酰胺（PA）暴露对幼龄鲫鱼神经毒性、应激指标和免疫反应的毒性标准以及潜在风险和影响。水生环境中存在大量微塑料（MPs），对水生生物产生各种有害影响。将平均体重为23.7±1.6克、平均体长为13.9±1.4厘米的鲫鱼暴露于浓度为0、4、8、16、32和64毫克/升的PA中2周。在神经递质中，PA暴露显著抑制了鲫鱼肝脏、鳃和肠道中的乙酰胆碱酯酶（AChE）活性。鲫鱼肝脏、鳃和肠道中的应激指标如皮质醇和热休克蛋白70（HSP70）显著升高，而对溶菌酶和免疫球蛋白M（IgM）的免疫反应显著降低。我们的研究证明了MP暴露对鲫鱼神经毒性、应激指标和免疫反应的毒性作用。
