School of Pharmacy, Jiangsu Province Engineering Research Center of Tumor Targeted Nano Diagnostic and Therapeutic Materials, Yancheng Teachers University, Yancheng 224007, Jiangsu Province, China.
School of Pharmacy, Jiangsu Province Engineering Research Center of Tumor Targeted Nano Diagnostic and Therapeutic Materials, Yancheng Teachers University, Yancheng 224007, Jiangsu Province, China.
Spectrochim Acta A Mol Biomol Spectrosc. 2024 Jan 5;304:123437. doi: 10.1016/j.saa.2023.123437. Epub 2023 Sep 20.
Beta-hydroxybutyrate (β-HB) serve as a valuable diagnostic biomarker for Diabetic Ketoacidosis (DKA). Here, a new Schiff base fluorescent probe T was designed and synthesized to detect β-HB level in aqueous solution in vitro. The probe T can detect β-HB sensitively and selectively in DMF solution (5.0 × 10 M) among other interfering species (cations, anions, amino acids, biomarkers). The detection limit of probe T for β-HB was calculated to be 0.154 μM. These results demonstrate that the probe T may provide a convenient method for rapid detection of β-HB to diagnose diabetic ketoacidosis.
β-羟丁酸（β-HB）可作为诊断糖尿病酮症酸中毒（DKA）的有价值的生物标志物。在这里，设计并合成了一种新的席夫碱荧光探针 T，以在体外的水溶液中检测β-HB 水平。探针 T 可以在 DMF 溶液（5.0×10 M）中灵敏且选择性地检测β-HB，而其他干扰物质（阳离子、阴离子、氨基酸、生物标志物）则不会产生影响。探针 T 对β-HB 的检测限计算为 0.154 μM。这些结果表明，探针 T 可能为快速检测β-HB 以诊断糖尿病酮症酸中毒提供了一种便捷的方法。
